HDAC Inhibitors as Epigenetic Regulators of the Immune System: Impacts on Cancer Therapy and Inflammatory Diseases

Table 2

Assays to assess HDAC inhibitor effects.

Cell-based assays	References
Apoptosis	[1, 33, 42–44]
Cell cycle arrest	[1, 3, 12, 45, 46]
Cytotoxicity	[40, 41, 47]
Differentiation	[2, 4]
Gene expression	[1, 3, 33, 40]
Growth arrest	[2, 3, 11]
Gene expression changes	[1, 3, 33, 40]
Histone hyperacetylation	[1, 3, 12, 39, 40, 47, 48]
Inflammation	[48–50]
Motility	[1, 19, 26]
ROS induction	[43, 51]
Senescence	[52–54]
Viability	[1, 12, 40]
In vivo assays	References
Antiangiogenesis	[5, 6]
Drug seeking behavior	[55]
Oncogenesis	[1, 40, 56, 57]
Senescence	[58]
Thermogenesis	[59]