BioMed Research International / 2016 / Article / Tab 3

Review Article

HDAC Inhibitors as Epigenetic Regulators of the Immune System: Impacts on Cancer Therapy and Inflammatory Diseases

Table 3

Effects of acetylation of nonhistone proteins by HDAC inhibitors.

Nonhistone proteinsClassification of proteinFunction of acetylationReferences

Increased DNA binding affinity[66]
p53Tumor suppressorIncreased transcriptional activation[6668]
Increased protein stability[68, 69]

RUNX3Tumor suppressorIncreased transcriptional activation[70]
Increased protein stability[70]

Increased DNA binding affinity[7072]
STAT3Signaling mediatorIncreased transcriptional activation[71, 72]
Promotes protein-protein interaction[71, 72]

β-cateninSignaling mediatorPromotes nuclear localization[73]

Increased transcriptional activation (basal)[74]
Estrogen receptorSteroid hormone receptorDecreased transcriptional activation (ligand dependent)[74]
Increased protein stability[75]

MycTranscription factorIncreased protein stability[76, 77]

EKLFTranscription factorPromotes protein-protein interaction[78]
Increased transcriptional activation[79]

Increased DNA binding affinity[80, 81]
E2F1Transcription factorIncreased transcriptional activation[80, 81]
Increased protein stability[80]

GATA familyTranscription factorIncreased DNA binding affinity[82, 83]
Increased transcriptional activation[8284]

HIF-1αTranscription factorDecreased transcriptional activation[85]
Decreased protein stability[85]

MyoDTranscription factorIncreased DNA binding affinity[86]
Increased transcriptional activation[8688]

NF-κBTranscription factorDisrupts protein-protein interaction[89]

Foxp3Transcription factorIncreased stability[90]