HDAC Inhibitors as Epigenetic Regulators of the Immune System: Impacts on Cancer Therapy and Inflammatory Diseases

Table 3

Effects of acetylation of nonhistone proteins by HDAC inhibitors.


Nonhistone proteins	Classification of protein	Function of acetylation	References

		Increased DNA binding affinity	[66]
p53	Tumor suppressor	Increased transcriptional activation	[66–68]
		Increased protein stability	[68, 69]

RUNX3	Tumor suppressor	Increased transcriptional activation	[70]
RUNX3	Tumor suppressor	Increased protein stability	[70]

		Increased DNA binding affinity	[70–72]
STAT3	Signaling mediator	Increased transcriptional activation	[71, 72]
		Promotes protein-protein interaction	[71, 72]

β-catenin	Signaling mediator	Promotes nuclear localization	[73]

		Increased transcriptional activation (basal)	[74]
Estrogen receptor	Steroid hormone receptor	Decreased transcriptional activation (ligand dependent)	[74]
		Increased protein stability	[75]

Myc	Transcription factor	Increased protein stability	[76, 77]

EKLF	Transcription factor	Promotes protein-protein interaction	[78]
EKLF	Transcription factor	Increased transcriptional activation	[79]

		Increased DNA binding affinity	[80, 81]
E2F1	Transcription factor	Increased transcriptional activation	[80, 81]
		Increased protein stability	[80]

GATA family	Transcription factor	Increased DNA binding affinity	[82, 83]
GATA family	Transcription factor	Increased transcriptional activation	[82–84]

HIF-1α	Transcription factor	Decreased transcriptional activation	[85]
HIF-1α	Transcription factor	Decreased protein stability	[85]

MyoD	Transcription factor	Increased DNA binding affinity	[86]
MyoD	Transcription factor	Increased transcriptional activation	[86–88]

NF-κB	Transcription factor	Disrupts protein-protein interaction	[89]

Foxp3	Transcription factor	Increased stability	[90]

BioMed Research International

HDAC Inhibitors as Epigenetic Regulators of the Immune System: Impacts on Cancer Therapy and Inflammatory Diseases

Table 3