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BioMed Research International
Volume 2016, Article ID 8957307, 13 pages
Research Article

Time-Dependent Regional Myocardial Strains in Patients with Heart Failure with a Preserved Ejection Fraction

1Division of Cardiothoracic Surgery, Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198, USA
2Department of Physiology, University of Arizona, Tucson, AZ 85724, USA
3Program in Applied Mathematics, University of Arizona, Tucson, AZ 85721, USA

Received 27 August 2015; Revised 11 January 2016; Accepted 24 January 2016

Academic Editor: Evren Caglayan

Copyright © 2016 Shane P. Smith et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. To better understand the etiology of HFpEF in a controlled human population, regional time-varying strains were computed using echocardiography speckle tracking in patients with heart failure with a preserved ejection fraction and normal subjects. Methods. Eleven normal volunteers and ten patients with echo-graded diastolic dysfunction and symptoms of heart failure were imaged with echocardiography and longitudinal, circumferential, and rotational strains were determined using speckle-tracking. Diastolic strain rate was also determined. Patient demographics and echo-derived flows, volumes, and pressures were recorded. Results. Peak longitudinal and circumferential strain was globally reduced in patients (), when compared to controls. The patients attained peak longitudinal and circumferential strain at a consistently later point in systole than controls. Rotational strains were not different in most LV regions. Early diastolic strain rate was significantly reduced in the patients (). LV mass and wall thickness were significantly increased in the patients; however ejection fraction was preserved and stroke volume was diminished (). Conclusions. This study shows that patients with HFpEF have reduced early diastolic strain rate and reduced peak strain that is regionally homogeneous and that they also utilize a longer fraction of systole to achieve peak axial strains.