Tricholoma matsutake Aqueous Extract Induces Hepatocellular Carcinoma Cell Apoptosis via Caspase-Dependent Mitochondrial Pathway

Figure 4

14-day TM (1 g/kg) administration suppressed tumor growth in HepG2-xenografted nude mouse models. (a) Tumor-possessing nude mice and (b) tumor tissues separated from CTRL and TM-treated groups. (c) Tumor volumes were measured every other day. Tumor size in the curve is expressed as mean ± SD (). and versus control group. (d) Mean (±SD) body weight of TM-treated and CTRL group (). (e) TM robustly enhanced the expressions of cleaved-PARP, Bad, and Bax in tumor tissues. Quantification data of protein expressions were normalized by corresponding GAPDH and the average fold of band intensity was marked, respectively (). (f) The histopathological examination of liver in tumor mouse models.

(a)

(b)

(c)

(d)

(e)

(f)