Vibration Induces BAFF Overexpression and Aberrant O-Glycosylation of IgA1 in Cultured Human Tonsillar Mononuclear Cells in IgA Nephropathy

Figure 4

The gene expression of C1GALT1 (a) and Cosmc (b) mRNA of TMCs subjected to different time periods of vibration. Data are mean ± SEM. The symbol indicates significant difference from control (0 min) of IgAN group (). (c) and (d) show negative correlation between aberrant O-glycosylation IgA1 level and C1GALT1 (, ) and aberrant O-glycosylation IgA1 level and Cosmc (, ). TMC, tonsillar mononuclear cells; C1GALT1, core β1,3-galactosyltransferase; Cosmc, core β1,3GalT-specific molecular chaperone; IgAN, Immunoglobulin A nephropathy; SEM, standard error of the mean.

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