Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2016, Article ID 9132840, 8 pages
http://dx.doi.org/10.1155/2016/9132840
Research Article

Design of Infusion Schemes for Neuroreceptor Imaging: Application to [11C]Flumazenil-PET Steady-State Study

1Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
2PET and Cyclotron Unit, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
3Heart Centre, Aarhus University Hospital, Noerrebrogade 44, 8000 Aarhus, Denmark
4Faculty of Health and Medicine Sciences, Copenhagen University, Blegdamsvej 3, 2200 Copenhagen, Denmark
5Danish Research Centre Magnetic Resonance, Copenhagen University Hospital, Hvidovre Hospital, Kettegaard Allé 30, 2650 Hvidovre, Denmark
6Epilepsy Clinic, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark

Received 4 January 2016; Accepted 13 March 2016

Academic Editor: Olaf Prante

Copyright © 2016 Ling Feng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. A. Lammertsma and S. P. Hume, “Simplified reference tissue model for PET receptor studies,” NeuroImage, vol. 4, no. 3, pp. 153–158, 1996. View at Publisher · View at Google Scholar · View at Scopus
  2. L. H. Pinborg, C. Videbaek, M. Ziebell et al., “[123I]epidepride binding to cerebellar dopamine D2/D3 receptors is displaceable: implications for the use of cerebellum as a reference region,” NeuroImage, vol. 34, no. 4, pp. 1450–1453, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. L. Feng, C. Svarer, G. Thomsen et al., “In vivo quantification of cerebral translocator protein binding in humans using 6-chloro-2-(4′-123I-iodophenyl)-3-(N,N-diethyl)-imidazo[1,2-a]pyridine-3-acetamide SPECT,” Journal of Nuclear Medicine, vol. 55, no. 12, pp. 1966–1972, 2014. View at Publisher · View at Google Scholar · View at Scopus
  4. N. A. Lassen, “Neuroreceptor quantitation in vivo by the steady-state principle using constant infusion or bolus injection of radioactive tracers,” Journal of Cerebral Blood Flow and Metabolism, vol. 12, no. 5, pp. 709–716, 1992. View at Publisher · View at Google Scholar · View at Scopus
  5. R. E. Carson, M. A. Charming, R. G. Blasberg et al., “Comparison of bolus and infusion methods for receptor quantitation: application to [18F]cyclofoxy and positron emission tomography,” Journal of Cerebral Blood Flow and Metabolism, vol. 13, no. 1, pp. 24–42, 1993. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Maziere, P. Hantraye, C. Prenant, J. Sastre, and D. Comar, “Synthesis of ethyl 8-fluoro-5,6-dihydro5- [11C]methyl-6-oxo-4H-imidazo[1,5-a] [1,4]benzodiazepine-3-carboxylate (RO 15.1788-11C): a specific radioligand for the in vivo study of central benzodiazepine receptors by positron emission tomography,” The International Journal of Applied Radiation and Isotopes, vol. 35, no. 10, pp. 973–976, 1984. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Hammers, P. Panagoda, R. A. Heckemann et al., “[11C]Flumazenil PET in temporal lobe epilepsy: do we need an arterial input function or kinetic modeling?” Journal of Cerebral Blood Flow and Metabolism, vol. 28, no. 1, pp. 207–216, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. I. Miederer, S. I. Ziegler, C. Liedtke et al., “Kinetic modelling of [11C]flumazenil using data-driven methods,” European Journal of Nuclear Medicine and Molecular Imaging, vol. 36, no. 4, pp. 659–670, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. S. M. Sanabria-Bohórquez, A. Maes, P. Dupont et al., “Image-derived input function for [11C]flumazenil kinetic analysis in human brain,” Molecular Imaging and Biology, vol. 5, no. 2, pp. 72–78, 2003. View at Publisher · View at Google Scholar · View at Scopus
  10. U. M. H. Klumpers, D. J. Veltman, R. Boellaard et al., “Comparison of plasma input and reference tissue models for analysing [11C]flumazenil studies,” Journal of Cerebral Blood Flow and Metabolism, vol. 28, no. 3, pp. 579–587, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. R. A. Koeppe, V. A. Holthoff, K. A. Frey, M. R. Kilbourn, and D. E. Kuhl, “Compartmental analysis of [11C]flumazenil kinetics for the estimation of ligand transport rate and receptor distribution using positron emission tomography,” Journal of Cerebral Blood Flow and Metabolism, vol. 11, no. 5, pp. 735–744, 1991. View at Publisher · View at Google Scholar · View at Scopus
  12. K. Någren and C. Halldin, “Methylation of amide and thiol functions with [11C]methyl triflate, as exemplified by [11C]NMSP, [11C]flumazenil and [11C]methionine,” Journal of Labelled Compounds and Radiopharmaceuticals, vol. 41, no. 9, pp. 831–841, 1998. View at Publisher · View at Google Scholar · View at Scopus
  13. D. M. Jewett, “A simple synthesis of [11C]methyl triflate,” International Journal of Radiation Applications and Instrumentation A, vol. 43, no. 11, pp. 1383–1385, 1992. View at Publisher · View at Google Scholar · View at Scopus
  14. R. P. Woods, S. R. Cherry, and J. C. Mazziotta, “Rapid automated algorithm for aligning and reslicing pet images,” Journal of Computer Assisted Tomography, vol. 16, no. 4, pp. 620–633, 1992. View at Publisher · View at Google Scholar · View at Scopus
  15. J. Ashburner and K. Friston, “Multimodal image coregistration and partitioning—a unified framework,” NeuroImage, vol. 6, no. 3, pp. 209–217, 1997. View at Publisher · View at Google Scholar · View at Scopus
  16. C. Svarer, K. Madsen, S. G. Hasselbalch et al., “MR-based automatic delineation of volumes of interest in human brain PET images using probability maps,” NeuroImage, vol. 24, no. 4, pp. 969–979, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. O. Eriksson, A. Wallberg, S. Syvänen, R. Josephsson, B. Lngström, and M. Bergström, “A computerized infusion pump for control of tissue tracer concentration during positron emission tomography in vivo pharmacokinetic/pharmacodynamic measurements,” BMC Medical Physics, vol. 8, no. 1, article 2, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. Y. Kimura, F. G. Siméon, S. S. Zoghbi et al., “Quantification of metabotropic glutamate subtype 5 receptors in the brain by an equilibrium method using 18F-SP203,” NeuroImage, vol. 59, no. 3, pp. 2124–2130, 2012. View at Publisher · View at Google Scholar · View at Scopus