Design of Infusion Schemes for Neuroreceptor Imaging: Application to [¹¹C]Flumazenil-PET Steady-State Study

Table 2

Metabolite-corrected plasma time-activity curve fitting.

	a1 (min^−1)	b1 (min^−1)	a1/b1	a2 (min^−1)	b2 (min^−1)	a2/b2	a3 (min^−1)	b3 (min^−1)	a3/b3
Bolus-1	2.503	2.579	0.97	0.109	0.107	1.02	0.045	0.010	4.56
Bolus-2	0.394	0.765	0.52	5.125	6.302	0.81	0.079	0.022	3.61
Bolus-3	0.455	0.860	0.53	6.353	7.990	0.80	0.103	0.029	3.58
Bolus-4	4.233	5.103	0.83	0.157	0.134	1.17	0.065	0.017	3.89
Bolus-5	6.544	7.142	0.92	0.189	0.178	1.06	0.086	0.018	4.79
Mean ± SD			0.75 ± 0.22			0.97 ± 0.16			4.09 ± 0.56

Note: and are the rate constants of the impulse response function to represent the concentration of parent radioligand in arterial plasma; see (1).