Design of Infusion Schemes for Neuroreceptor Imaging: Application to [11C]Flumazenil-PET Steady-State Study
Table 3
Model parameters of one-tissue compartment model (1TC) and steady-state approaches: programmed infusion (PI) and bolus infusion (BI).
1TC
PI
BI
(mL min−1 mL−1)
(min−1)
Occipital cortex
0.43 ± 0.07
0.05 ± 0.01
8.05 ± 0.56
9.00 ± 1.56
8.89 ± 1.73
Neocortex
0.41 ± 0.06
0.06 ± 0.01
7.36 ± 0.46
8.16 ± 1.30
7.97 ± 1.60
Hippocampus
0.28 ± 0.04
0.05 ± 0.01
6.11 ± 0.49
6.79 ± 1.44
6.57 ± 1.42
Cerebellum
0.41 ± 0.06
0.08 ± 0.01
4.97 ± 0.70
5.62 ± 0.85
5.39 ± 1.12
Thalamus
0.44 ± 0.06
0.11 ± 0.01
4.13 ± 0.38
4.83 ± 1.11
4.66 ± 0.93
Pallidostriatum
0.45 ± 0.07
0.13 ± 0.02
3.35 ± 0.34
3.86 ± 0.93
3.83 ± 0.75
Midbrain
0.25 ± 0.04
0.16 ± 0.01
1.59 ± 0.17
2.05 ± 0.31
1.92 ± 0.28
White matter
0.11 ± 0.02
0.12 ± 0.01
0.93 ± 0.08
1.12 ± 0.13
1.11 ± 0.20
Pons
0.31 ± 0.06
0.33 ± 0.04
0.91 ± 0.09
1.10 ± 0.15
0.85 ± 0.07
The mean and standard deviation are reported. is defined as for 1TC and for PI and BI averaging from 35 to 80 min after the beginning of tracer administration.
