Impacts of Nonsynonymous Single Nucleotide Polymorphisms of Adiponectin Receptor 1 Gene on Corresponding Protein Stability: A Computational Approach

Figure 4

ADIPOR1 protein-protein interactions with 10 partners. One color is specified for each type of evidence in the predicted functional links (edges) among eight colored lines. (a) Only APPL1 with score of 0.985 is observed for interaction with ADIPOR1 by experimental and text-mining basis. From text-mining data, ADIPOR1 interactions are detected for ADIPOQ, APPL1, LEP, INS, STAT3, C1QTNF9, MYC, MMP3, SGPL1, and LTBR proteins with 0.994, 0.985, 0.942, 0.941, 0.865, 0.862, 0.833, 0.828, 0.806, and 0.804 scores, respectively. (b) Strong association pattern (thick blue lines) of ADIPOR1 is predicted for ADIPOQ, APPL1, LEP, and INS partners with high confidence. The remaining partners have weak association and shown in the form of thin blue lines.