Impacts of Nonsynonymous Single Nucleotide Polymorphisms of Adiponectin Receptor 1 Gene on Corresponding Protein Stability: A Computational Approach

Table 3

A list of selected variants for analyzing SNPeffect and I-Mutant tools.

Amino acid change	SNPeffect				I-Mutant
	TANGO; Aggregation tendency; (dTANGO score)	WALTZ; Amyloid propensity; (dWALTZ score)	LIMBO; Chaperone binding tendency; (dLIMBO score)	FoldX; Protein stability	Prediction	RI
A348G	Not affected	Not affected	Not affected	NP	Decrease	8
	(−39.32)	(46.87)	(0.00)
H341Y	Increased	Decreased	Not affected	NP	Increase	3
	(222.09)	(−241.53)	(0.00)
R324L	Not affected	Not affected	Not affected	NP	Decrease	7
	(−1.01)	(0.49)	(0.00)
L224F	Increased	Not affected	Not affected	NP	Decrease	8
	(51.62)	(−46.88)	(0.00)
L143P	Decreased	Not affected	Not affected	NP	Decrease	4
	(−230.61)	(2.58)	(0.00)