Impacts of Nonsynonymous Single Nucleotide Polymorphisms of Adiponectin Receptor 1 Gene on Corresponding Protein Stability: A Computational Approach

Table 4

Surface accessibility of wild type and mutants of ADIPOR1 protein.

Amino acid change	Class assignment	Relative surface accessibility (RSA)	Absolute surface accessibility	-fit score for RSA prediction
A348G	Buried	0.094	10.403	−0.412
	Buried	0.093	7.288	−0.405
H341Y	Buried	0.070	12.769	0.848
	Buried	0.063	13.463	0.712
R324L	Exposed	0.34	77.860	−0.843
	Exposed	0.352	64.470	−0.734
L224F	Buried	0.029	5.273	−0.077
	Buried	0.027	5.519	0.018
L143P	Exposed	0.305	55.937	−0.824
	Exposed	0.329	46.628	−0.942