Micronucleated Erythrocytes in Peripheral Blood from Neonate Rats Exposed by Breastfeeding to Cyclophosphamide, Colchicine, or Cytosine-Arabinoside
Table 1
MNPCE frequencies from dams of rat study groups at different sampling times.
Groups
0 h
24 h
48 h
72 h
96 h
120 h
Negative control
1.40 ± 0.89
1.80 ± 1.30
1.80 ± 0.84
1.60 ± 1.14
2.00 ± 1.30
2.20 ± 1.30
CP lower-dose
1.20 ± 0.83
4.47 ± 1.45
13.47 ± 3.53
12.07 ± 3.61
7.33 ± 3.48
2.53 ± 1.12
CP middle-dose
1.60 ± 0.89
3.47 ± 1.61
20.60 ± 4.34
13.40 ± 3.58
14.07 ± 4.75
2.07 ± 0.86
CP higher-dose
1.27 ± 0.43
6.73 ± 2.12
24.33 ± 5.25
20.20 ± 6.21
16.80 ± 4.27
3.60 ± 1.38
COL lower-dose
1.00 ± 0.71
3.00 ± 0.71
5.00 ± 1.87
7.60 ± 2.40
7.20 ± 1.64
3.00 ± 1.22
COL middle-dose
1.20 ± 0.45
3.80 ± 1.79
7.00 ± 1.22
7.60 ± 2.51
6.00 ± 2.55
3.20 ± 0.84
COL higher-dose
1.20 ± 0.84
3.60 ± 1.52
5.80 ± 1.92
6.40 ± 2.40
6.40 ± 2.41
3.60 ± 1.82
AraC lower-dose
1.20 ± 0.84
3.80 ± 1.79
9.20 ± 2.38
8.00 ± 2.74
3.60 ± 0.89
1.80 ± 0.45
AraC middle-dose
1.20 ± 1.10
5.60 ± 1.82
8.80 ± 2.39
7.80 ± 1.30
5.80 ± 1.30
3.40 ± 1.52
AraC higher-dose
1.40 ± 0.89
7.40 ± 2.07
9.00 ± 2.00
8.20 ± 2.49
8.00 ± 2.00
3.40 ± 1.51
Data () expressed as mean ± standard deviation per group of MNPCEs/1,000 PCEs. MNPCEs: micronucleated polychromatic erythrocytes, PCEs: polychromatic erythrocytes, h: hours, and NS: not significant. group comparisons. group comparisons between negative control groups versus the other groups.
