Micronucleated Erythrocytes in Peripheral Blood from Neonate Rats Exposed by Breastfeeding to Cyclophosphamide, Colchicine, or Cytosine-Arabinoside
Table 2
PCE frequencies from dams of rat study groups at the different sampling times.
Groups
0 h
24 h
48 h
72 h
96 h
120 h
Negative control
78.00 ± 27.17
84.20 ± 29.77
79.60 ± 25.40
88.00 ± 23.39
81.80 ± 23.42
89.40 ± 22.43
CP lower-dose
83.20 ± 20.33
82.20 ± 53.89
82.20 ± 45.06
83.40 ± 46.95
80.60 ± 30.66
86.60 ± 46.12
CP middle-dose
74.60 ± 23.33
84.40 ± 37.66
78.80 ± 58.31
68.80 ± 41.15
76.20 ± 23.84
83.40 ± 30.30
CP higher-dose
77.40 ± 10.71
56.40 ± 19.83
48.80 ± 19.86
34.40 ± 16.41
30.20 ± 17.02
44.20 ± 16.97
COL lower-dose
90.80 ± 44.42
100.00 ± 60.46
92.00 ± 45.91
93.20 ± 43.89
99.00 ± 49.40
97.20 ± 57.93
COL middle-dose
87.20 ± 42.71
97.40 ± 52.79
105.60 ± 54.24
129.00 ± 38.40
106.00 ± 37.28
102.40 ± 60.16
COL higher-dose
81.80 ± 28.09
99.60 ± 63.70
89.40 ± 38.37
131.40 ± 61.67
119.40 ± 43.84
97.00 ± 39.86
AraC lower-dose
83.40 ± 23.44
95.80 ± 56.98
99.60 ± 52.55
94.80 ± 60.72
105.00 ± 61.70
105.60 ± 76.51
AraC middle-dose
82.60 ± 24.78
82.20 ± 28.38
103.40 ± 65.58
106.60 ± 62.77
95.80 ± 41.43
102.40 ± 38.41
AraC higher-dose
82.20 ± 26.48
86.00 ± 49.10
95.00 ± 35.62
83.80 ± 34.60
98.80 ± 51.84
89.60 ± 22.22
Data () expressed as mean ± standard deviation per group of PCEs/1,000 TEs. PCEs: polychromatic erythrocytes, TEs: total erythrocytes, h: hours, and NS: not significant. group comparisons. group comparisons between negative control groups versus the other groups.
