Micronucleated Erythrocytes in Peripheral Blood from Neonate Rats Exposed by Breastfeeding to Cyclophosphamide, Colchicine, or Cytosine-Arabinoside
Table 3
MNE frequencies from pup samples of rat study groups at different sampling times.
Groups
0 h
24 h
48 h
72 h
96 h
120 h
Negative control
2.25 ± 0.6
2.34 ± 0.5
2.48 ± 0.7
2.37 ± 0.6
2.55 ± 0.6
2.51 ± 0.7
CP lower-dose
2.21 ± 0.3
2.77 ± 0.6
3.76 ± 1.1
4.62 ± 1.0
4.51 ± 1.0
4.11 ± 1.0
CP middle-dose
2.13 ± 0.8
2.47 ± 0.8
3.27 ± 0.9
3.87 ± 1.2
3.81 ± 1.1
3.60 ± 1.2
CP higher-dose
2.46 ± 0.6
2.68 ± 0.9
3.65 ± 0.9
4.07 ± 1.0
3.97 ± 0.8
4.08 ± 1.2
COL lower-dose
2.68 ± 0.6
3.24 ± 1.0
3.58 ± 1.1
4.13 ± 1.2
4.17 ± 1.0
4.07 ± 1.1
COL middle-dose
2.41 ± 0.8
3.03 ± 0.8
3.62 ± 1.2
3.80 ± 0.9
3.96 ± 1.5
4.27 ± 1.2
COL higher-dose
2.75 ± 0.8
4.13 ± 1.1
4.77 ± 1.2
4.40 ± 1.5
5.00 ± 1.4
5.09 ± 1.5
AraC lower-dose
2.20 ± 1.2
2.93 ± 1.5
3.45 ± 1.1
3.25 ± 1.3
2.78 ± 1.5
2.24 ± 1.1
AraC middle-dose
2.62 ± 1.2
3.40 ± 1.5
3.75 ± 1.1
3.78 ± 1.5
3.28 ± 1.8
3.23 ± 1.6
AraC higher-dose
2.55 ± 0.6
4.14 ± 1.9
3.72 ± 1.5
3.36 ± 0.9
3.33 ± 1.0
3.44 ± 1.6
Data () expressed as mean ± standard deviation per group of MNEs/1,000 TEs. MNEs: micronucleated erythrocytes, TEs: total erythrocytes, h: hours, and NS: not significant. group comparisons. group comparisons between negative control groups versus the other groups.
