Micronucleated Erythrocytes in Peripheral Blood from Neonate Rats Exposed by Breastfeeding to Cyclophosphamide, Colchicine, or Cytosine-Arabinoside
Table 4
MNPCE frequencies from pup samples of rat study groups at different sampling times.
Groups
0 h
24 h
48 h
72 h
96 h
120 h
Negative control
3.75 ± 1.6
3.80 ± 1.6
4.15 ± 1.8
4.30 ± 1.9
4.30 ± 1.4
4.25 ± 1.4
CP lower-dose
3.75 ± 1.8
5.00 ± 2.4
6.80 ± 2.1
7.75 ± 2.3
7.75 ± 2.1
7.45 ± 2.2
CP middle-dose
3.00 ± 1.3
4.80 ± 1.8
6.70 ± 2.5
7.75 ± 3.5
9.30 ± 4.3
7.65 ± 3.9
CP higher-dose
3.60 ± 1.5
5.35 ± 2.3
7.40 ± 3.7
9.70 ± 4.2
8.70 ± 3.3
7.00 ± 3.4
COL lower-dose
4.45 ± 1.4
4.80 ± 2.0
6.65 ± 2.9
7.15 ± 2.7
6.90 ± 2.4
7.25 ± 2.9
COL middle-dose
4.60 ± 1.9
5.40 ± 2.5
7.40 ± 3.9
6.85 ± 3.3
7.10 ± 2.2
6.75 ± 3.4
COL higher-dose
4.80 ± 1.6
6.70 ± 2.7
7.50 ± 2.0
6.70 ± 1.9
7.95 ± 3.2
7.25 ± 2.6
AraC lower-dose
2.50 ± 1.2
5.1 ± 2.7
9.60 ± 5.6
7.10 ± 5.7
6.25 ± 2.9
2.95 ± 1.4
AraC middle-dose
2.65 ± 1.2
4.55 ± 1.3
7.95 ± 3.3
7.65 ± 3.2
5.30 ± 2.4
5.15 ± 2.5
AraC higher-dose
2.75 ± 1.4
7.10 ± 3.4
8.75 ± 3.0
6.45 ± 1.8
5.25 ± 2.3
4.00 ± 2.6
Data () expressed as mean ± standard deviation per group of MNPCEs/1,000 PCEs. MNPCEs: micronucleated polychromatic erythrocytes, PCEs: polychromatic erythrocytes, h: hours, and NS: not significant. group comparisons. group comparisons between negative control groups versus the other groups.
