Micronucleated Erythrocytes in Peripheral Blood from Neonate Rats Exposed by Breastfeeding to Cyclophosphamide, Colchicine, or Cytosine-Arabinoside
Table 5
PCE frequencies of pup samples of rat study groups at the different sampling times.
Groups
0 h
24 h
48 h
72 h
96 h
120 h
Negative control
608.8 ± 160.7
430.7 ± 86.8
373.9 ± 89.1
375.4 ± 100.5
389.0 ± 71.9
394.9 ± 67.2
CP lower-dose
605.0 ± 138.7
432.7 ± 91.6
397.1 ± 68.1
413.7 ± 89.7
405.2 ± 81.5
401.3 ± 70.9
CP middle-dose
618.8 ± 120.6
413.6 ± 94.4
338.7 ± 80.7
342.6 ± 53.6
362.5 ± 59.0
399.2 ± 82.1
CP higher-dose
632.6 ± 138.0
457.0 ± 100.5
379.3 ± 80.6
352.3 ± 81.9
379.9 ± 55.3
388.7 ± 92.0
COL lower-dose
621.1 ± 129.7
490.0 ± 95.5
391.5 ± 79.9
407.3 ± 63.1
415.3 ± 69.3
441.6 ± 66.4
COL middle-dose
571.6 ± 138.2
468.6 ± 94.6
389.2 ± 56.2
380.7 ± 119.2
396.7 ± 54.1
419.8 ± 77.8
COL higher-dose
667.2 ± 73.5
483.2 ± 114.5
392.5 ± 61.4
429.5 ± 58.6
457.5 ± 63.0
440.5 ± 65.2
AraC lower-dose
606.2 ± 133.8
344.8 ± 102.0
373.9 ± 72.0
391.9 ± 70.3
392.8 ± 61.8
433.5 ± 62.3
AraC middle-dose
555.8 ± 106.9
393.8 ± 89.4
327.2 ± 49.4
381.9 ± 87.8
439.6 ± 78.1
498.3 ± 81.1
AraC higher-dose
535.5 ± 153.7
404.8 ± 73.6
361.2 ± 65.0
335.2 ± 60.7
386.9 ± 77.2
424.9 ± 102.0
Data () expressed as mean ± standard deviation per group of PCEs/1,000 TEs. PCEs: polychromatic erythrocytes, TEs: total erythrocytes, h: hours, and NS: not significant. group comparisons. group comparisons between negative control groups versus the other groups.
