Two-Dimensional Speckle Tracking Echocardiography Detects Subclinical Left Ventricular Systolic Dysfunction among Adult Survivors of Childhood, Adolescent, and Young Adult Cancer
Table 1
Demographics and treatment characteristics ().
Characteristic
No.
%
Mean
SD
Current age, years
31.4
8.8
Median
30.5
Range
18.1–62.6
Age at diagnosis, years
16.0
9.0
Median
15.8
Range
0–48.7
Interval since diagnosis, years
15.4
9.4
Median
15
Range
2.4–39.6
Sex
Male
73
54.5
Female
61
45.5
Race
Non-Hispanic white
114
85.1
Black
9
6.7
Other
11
8.2
Diagnosis
Sarcoma
54
40.2
Hodgkin lymphoma
29
21.6
Acute lymphoblastic leukemia
17
12.7
Acute myeloid leukemia
14
10.4
Non-Hodgkin lymphoma
9
6.7
Other
11
8.2
Anthracycline cumulative dose exposure
320
124
Median
300
Range
27–660
>350
57
42.5
150–350
58
43.3
1–150
19
14.2
Mediastinal RT dose, Gy
None
82
61.2
1–30
38
28.4
>30
14
10.4
Cardiovascular risk factors
Hypertension
12
9.0
Diabetes
7
5.2
Dyslipidemia
42
31.3
Treatment with beta-blockers or ACE-I
14
10.4
Body mass index
24.8
4.7
Median
23.9
Range
18.0–47.0
Overweight (BMI 25–<30)
39
29.1
Obese (BMI 30)
17
12.7
RT, radiotherapy; ACE-I, angiotensin converting enzyme inhibitor; BMI, body mass index; SD, standard deviation. Other: neuroblastoma (), chronic myeloid leukemia (), teratoma (), ependymoma (), nasopharyngeal carcinoma (), retinoblastoma (), and Wilms' tumor ().
