Two-Dimensional Speckle Tracking Echocardiography Detects Subclinical Left Ventricular Systolic Dysfunction among Adult Survivors of Childhood, Adolescent, and Young Adult Cancer
Table 2
LV size and function by receipt of mediastinal radiotherapy.
Total (overall)
Mediastinal radiotherapy
value
Yes ()
No ()
Fractional shortening, %
33.3 (30.4, 36.1)
33.3 (30.6, 36.0)
33.1 (29.9, 36.1)
0.948
Fractional shortening < 27%
7 (5.2)
5 (9.6)
2 (2.4)
NA
Ejection fraction, %
61.1 (58.0, 63.6)
60.7 (57.6, 63.4)
61.2 (58.1, 64.0)
0.457
Ejection fraction < 55%
8 (6.0)
5 (9.6)
3 (3.7)
NA
GLS, %
18.0 (17.0, 20.0)
18.0 (16.0, 19.5)
19.0 (17.0, 20.0)
0.040
GLS 16%
31 (23.1)
19 (36.5)
12 (14.6)
0.036
GLS (APLAX), %
18.0 (16.0, 20.0)
17.0 (15.0, 19.0)
19.0 (17.0, 21.0)
0.023
GLS (A4C), %
18.0 (16.0, 20.0)
17.0 (15.0, 19.0)
18.0 (17.0, 20.0)
0.010
GLS (A2C), %
19.0 (17.0, 21.0)
19.0 (16.5, 20.0)
19.0 (17.0, 21.0)
0.279
GLS rate, 1/s
1.1 (1.0, 1.2)
1.1 (1.0, 1.2)
1.1 (1.0, 1.2)
0.995
GRS, %
42.1 (31.1, 53.7)
42.1 (26.5, 55.2)
42.0 (31.9, 51.4)
0.843
GRS rate, 1/s
2.2 (1.9, 2.7)
2.3 (1.9, 2.9)
2.2 (1.9, 2.7)
0.086
GCS, %
17.3 (15.2, 19.7)
16.1 (14.5, 19.7)
17.6 (16.0, 19.7)
0.086
GCS rate, 1/s
1.5 (1.3, 1.8)
1.5 (1.3, 1.9)
1.4 (1.3, 1.8)
0.058
LV mass/BSA, g/m2
64.3 (55.9, 72.1)
63.1 (56.9, 69.2)
65.4 (55.6, 74.3)
0.099
Mitral ratio
1.5 (1.2, 1.8)
1.3 (1.0, 1.6)
1.6 (1.3, 1.9)
0.005
Septal , cm/s
10.4 (8.8, 12.3)
9.3 (8.3, 11.2)
11.6 (9.8, 12.6)
0.003
Numbers are median (interquartile range) for continuous variables and (%) for categorical variables. GLS, global longitudinal strain; APLAX, apical long axis; A4C, apical 4-chamber; A2C, apical 2 -hamber; LV, left ventricle; BSA, body surface area. value from multivariable linear or logistic regression adjusted for continuous cumulative anthracycline dose, sex, and age at echocardiogram. Based on only patients.
