Genetic Association of CHAT rs3810950 and rs2177369 Polymorphisms with the Risk of Alzheimer’s Disease: A Meta-Analysis

Table 1

The baseline characteristics of all the studies included in this meta-analysis.

	First author	Year	Area	Ethnicity	Number of cases	Number of controls	Cases			Controls			HWE	Genotyping	Diagnosis criteria	Statistical power
							G/G	G/A	A/A	G/G	G/A	A/A		method		Dominant/recessive
rs3810950	Mubumbila [13]	2002	France & Germany	Caucasian	122	112	48	32	42	64	34	14	0.016	SSCP-PCR^1	None	71.33%/98.68%
	Harold [20]	2003	UK	Caucasian	131	118	69	51	11	65	47	6	0.627	PCR-RFLP^2	NINCDS-ADRDA	6.62%/22.59%
	Kim [12]	2004	Korea	Asian	246	561	171	61	14	419	133	9	0.856	PCR/sequencing^2	NINCDS-ADRDA & DSM-IV	33.45%/94.29%
	Cook [21]	2005	UK	Caucasian	210	315	112	76	22	161	128	26	1	PCR-RFLP^2	NINCDS-ADRDA	8.26%/13.68%
	Ahn Jo [14]	2006	Korea	Asian	316	264	211	99	6	192	70	2	0.129	PCR/sequencing^2	NINCDS-ADRDA	35.87%/58.33%
	Ozturk [15]	2006	USA	Caucasian	999	708	562	377	60	363	296	49	0.304	PCR/sequencing^2	NINCDS-ADRDA	51.57%/11.65%
	Tang [16]	2008	China	Asian	273	271	190	75	8	179	83	9	1	PCR-RFLP^2	NINCDS-ADRDA	14.06%/5.73%
	Grünblatt [17]	2009	Austria	Caucasian	120	456	63	45	12	268	164	24	1	TaqMan^1	NINCDS-ADRDA	23.56%/47.82%
	Grünblatt [18]	2011	Austria & Italy	Caucasian	137	464	79	46	12	267	173	24	0.61	TaqMan^1	NINCDS-ADRDA	5.00%/35.07%
	Mengel-From [10]	2011	Denmark	Caucasian	661	1308	38	203	420	55	455	798	0.369	TaqMan^1	NINCDS-ADRDA	90.29%/7.57%
	Lee [19]	2012	Korea	Asian	736	1386	505	205	26	1023	342	21	0.26	RT-PCR^1	None	73.11%/94.39%
rs2177369	Cook (1) [21]	2005	UK	Caucasian	202	295	29	85	88	76	124	95	0.0073	PCR-RFLP^2	NINCDS-ADRDA	77.81%/71.82%
	Cook (2) [21]	2005	UK (Cardiff)	Caucasian	179	175	26	79	74	29	83	63	0.8754	PCR-RFLP^2	NINCDS-ADRDA	17.71%/7.82%
	Piccardi [22]	2007	Italy	Caucasian	158	118	44	75	39	40	57	21	1	PCR-RFLP^2	NINCDS-ADRDA & DSM-IV	36.06%/15.30%
	Scacchi [23]	2009	Italy	Caucasian	442	218	167	200	75	61	117	40	0.2737	PCR-RFLP^2	NINCDS-ADRDA	8.45%/56.24%

Note: ¹quantitative PCR and ²nonquantitative PCR.