Review Article

Genetic Association of CHAT rs3810950 and rs2177369 Polymorphisms with the Risk of Alzheimer’s Disease: A Meta-Analysis

Table 3

Subgroup analyses of the association between CHAT rs3810950 polymorphism and Alzheimer’s disease risk.

Genetic comparison (%)Effect modelOR [95% CI]Statistical power

OverallA versus G74Random1.18 [1.01, 1.37]0.03NA
AA versus GG72Random1.63 [1.09, 2.42]0.02NA
AG versus GG37Fixed0.99 [0.90, 1.10]0.87NA
AA + GA versus GG62Random1.08 [0.92, 1.28]0.3446.23%
AA versus GG + GA66Random1.65 [1.20, 2.26]0.0199.99%

Ethnicity-based
 Caucasian (7)A versus G77Random1.16 0.94, 1.420.16NA
AA versus GG74Random1.42 0.90, 2.250.13NA
AG versus GG0Fixed0.88 0.77, 1.000.06NA
AA + GA versus GG60Random1.02 0.82, 1.280.856.34%
AA versus GG + GA66Random1.47 1.05, 2.070.0399.99%

Ethnicity-based
 Asian (4)A versus G52Random1.23 1.01, 1.480.04NA
AA versus GG46Fixed2.24 1.48, 3.39<0.01NA
AG versus GG5Fixed1.15 0.99, 1.320.07NA
AA + GA versus GG33Fixed1.21 1.06, 1.40<0.0177.90%
AA versus GG + GA40Fixed2.18 1.45, 3.29<0.0199.45%

Genotyping-based
 Quantitative PCR (5)A versus G76.5Random1.32 1.05, 1.650.02NA
AA versus GG80.6Random1.89 1.00, 3.550.05NA
AG versus GG46.9Fixed1.08 0.93, 1.260.32NA
AA + GA versus GG64.3Random1.18 0.90, 1.550.2477.24%
AA versus GG + GA77.3Random1.94 1.18, 3.190.0199.99%

Genotyping-based
 Nonquantitative PCR (6)A versus G62.8Random1.06 0.88, 1.280.52NA
AA versus GG61.6Random1.40 0.82, 2.370.22NA
AG versus GG18.8Fixed0.93 0.82, 1.060.29NA
AA + GA versus GG48.4Fixed1.01 0.83, 1.210.955.11%
AA versus GG + GA55.7Random1.42 0.88, 2.290.1675.03%

Note: NA: not applicable.