Genetic Association of CHAT rs3810950 and rs2177369 Polymorphisms with the Risk of Alzheimer’s Disease: A Meta-Analysis

Table 5

Meta-analysis of the association between CHAT rs2177369 polymorphism and Alzheimer’s disease risk.

Meta-analysis	Genetic comparison	(%)	Effect model	OR [95% CI]		Statistical power
Overall	G versus A	82	Random	0.85 [0.61, 1.18]	0.34	NA
	GG versus AA	77	Random	0.73 [0.40, 1.32]	0.3	NA
	GA versus AA	0	Fixed	0.80 [0.63, 1.01]	0.06	NA
	GG + GA versus AA	32	Fixed	0.77 [0.62, 0.96]	0.02	69.05%
	GG versus AA + GA	82	Random	0.85 [0.49, 1.47]	0.55	30.29%
Analysis without Cook (1) study	G versus A	72	Random	0.96 [0.70, 1.31]	0.78	NA
	GG versus AA	62	Random	0.91 [0.52, 1.59]	0.73	NA
	GA versus AA	0	Fixed	0.83 [0.62, 1.10]	0.19	NA
	GG + GA versus AA	7	Fixed	0.87 [0.67, 1.14]	0.32	19.62%
	GG versus AA + GA	69	Random	1.04 [0.63, 1.71]	0.88	5.97%
Analysis without Scacchi study	G versus A	22	Fixed	0.73 [0.61, 0.86]	<0.01	NA
	GG versus AA	13	Fixed	0.54 [0.39, 0.76]	<0.01	NA
	GA versus AA	0	Fixed	0.76 [0.58, 0.99]	0.05	NA
	GG + GA versus AA	0	Fixed	0.68 [0.53, 0.88]	<0.01	86.83%
	GG versus AA + GA	26	Fixed	0.65 [0.48, 0.87]	<0.01	73.79%

Note: NA: not applicable.