BioMed Research International / 2016 / Article / Tab 2

Research Article

Urinary 3-(3-Hydroxyphenyl)-3-hydroxypropionic Acid, 3-Hydroxyphenylacetic Acid, and 3-Hydroxyhippuric Acid Are Elevated in Children with Autism Spectrum Disorders

Table 2

Predictive values for ASDs based on the three compounds.

TestTrue positive (sensitivity)False negative (1 − sensitivity)True negative (specificity)False positive (1 − specificity)Total

CriteriaHPHPA > 101.5 mmol/mol creatinine
Control61 (98.4%)1 (1.6%)62
ASDs45 (72.6%)17 (27.4%)62

Criteria3HPA > 45.2 mmol/mol creatinine
Control62 (100%)0 (0%)62
ASDs18 (29%)44 (71%)62

Criteria3HHA > 14.8 mmol/mol creatinine
Control60 (96.8%)2 (3.2%)62
ASDs21 (33.9%)41 (66.1%)62

CriteriaPrediction probability > 0.65 (based on the three metabolites)
Control98.4%1.6%
ASDs90.3%9.7%

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