Role of BK_Ca in Stretch-Induced Relaxation of Colonic Smooth Muscle

Figure 3

Effects of ChTX, TEA, and TTX on the muscle tone and contraction amplitude of colonic smooth muscle strips. (a) Effects of ChTX, a nonspecific blocker of B channels, on the activities of colonic longitudinal muscle. (b) Active contraction amplitude increased dose-dependently by ChTX. (c) ChTX had no effect on the muscle tone of the colon. (d) The effects of TEA, a nonspecific potassium channel blocker, on the activities of colonic longitudinal muscle. (e) Active contraction amplitude increased by TEA. (f) TEA had no effect on the muscle tone of the colon. (g) The effect of TTX, a specific voltage-gated sodium channel blocker, on the activities of the colonic longitudinal muscle. (h) and (i) TTX had no effect on the active contraction amplitude and the muscle tone of the colon. Values are shown as means ± SEM, = 6; < 0.05.

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