Efficacy and Safety of a Permethrin-Fipronil Spot-On Solution (Effitix®) in Dogs Naturally Infested by Ticks in Europe

Table 4

Assessment of the noninferiority for the Intention to Treat population.

		D7	D14	D21	D28
Arithmetic mean	Efficacy % P/F	91.8%	95.0%	97.5%	96.7%
	Efficacy % P/I	95.9%	97.4%	96.7%	92.1%
	Efficacy % P/F − P/I	−4.1%	−2.4%	0.7%	4.6%
	95% bootstrap CI	−8.98%; 0.48%	−9.34%; 2.42%	−2.94%; 4.60%	−1.76%; 13.41%
Geometric mean	Efficacy % P/F	91.2%	97.1%	98.3%	96.7%
	Efficacy % P/I	94.8%	96.9%	95.7%	94.6%
	Efficacy % P/F − P/I	−3.6%	0.2%	2.6%	2.1%
	95% bootstrap CI	−9.62%; 2.45%	−3.27%; 3.97%	−1.09%; 7.31%	−2.48%; 6.80%

CI: confidence interval, P/F: permethrin-fipronil spot-on (Effitix), and P/I: permethrin-imidacloprid spot-on (Advantix).