Research Article
Efficacy and Safety of a Permethrin-Fipronil Spot-On Solution (Effitix®) in Dogs Naturally Infested by Ticks in Europe
Table 4
Assessment of the noninferiority for the Intention to Treat population.
| | D7 | D14 | D21 | D28 |
| Arithmetic mean | Efficacy % P/F | 91.8% | 95.0% | 97.5% | 96.7% | Efficacy % P/I | 95.9% | 97.4% | 96.7% | 92.1% | Efficacy % P/F − P/I | −4.1% | −2.4% | 0.7% | 4.6% | 95% bootstrap CI | −8.98%; 0.48% | −9.34%; 2.42% | −2.94%; 4.60% | −1.76%; 13.41% |
| Geometric mean | Efficacy % P/F | 91.2% | 97.1% | 98.3% | 96.7% | Efficacy % P/I | 94.8% | 96.9% | 95.7% | 94.6% | Efficacy % P/F − P/I | −3.6% | 0.2% | 2.6% | 2.1% | 95% bootstrap CI | −9.62%; 2.45% | −3.27%; 3.97% | −1.09%; 7.31% | −2.48%; 6.80% |
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CI: confidence interval, P/F: permethrin-fipronil spot-on (Effitix), and P/I: permethrin-imidacloprid spot-on (Advantix).
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