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BioMed Research International
Volume 2016 (2016), Article ID 9507342, 9 pages
Research Article

The Synergistic Effect of Leukocyte Platelet-Rich Fibrin and Micrometer/Nanometer Surface Texturing on Bone Healing around Immediately Placed Implants: An Experimental Study in Dogs

1Department of Periodontology, University of Florida, 1395 Center Drive, D1-11, Gainesville, FL 32610, USA
2Department of Dentistry, Universidade Federal de Santa Catarina, R. Eng. Agronômico Andrei Cristian Ferreira, s/n Trindade, 88040-900 Florianópolis, SC, Brazil
3Department of Biomaterials and Biomimetics, New York University, 433 1st Ave., Room 844, New York, NY 10010, USA
4Department of Epidemiology and Health Promotion, New York University, 345 E 24th Street, New York, NY 10010, USA
5Department of Prosthodontics and Periodontology, University of Sao Paulo, Bauru School of Dentistry, Alameda Octávio Pinheiro Brisolla 9-75, 17.012-901 Bauru, SP, Brazil
6Department of Periodontics and Implant Dentistry, Faculty of Dentistry, University of the Andes (UANDES), Mons. Alvaro del Portillo 12.455, Las Condes, Santiago, Chile
7Hansjörg Wyss Department of Plastic Surgery, NYU Langone Medical Center, 550 1st Avenue, New York, NY 10016, USA

Received 3 August 2016; Accepted 3 November 2016

Academic Editor: Carmen Mortellaro

Copyright © 2016 Rodrigo F. Neiva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aims. This study evaluated the effects of L-PRF presence and implant surface texture on bone healing around immediately placed implants. Methods. The first mandibular molars of 8 beagle dogs were bilaterally extracted, and implants (Blossom™, Intra-Lock International, Boca Raton, FL) were placed in the mesial or distal extraction sockets in an interpolated fashion per animal. Two implant surfaces were distributed per sockets: (1) dual acid-etched (DAE, micrometer scale textured) and (2) micrometer/nanometer scale textured (Ossean™ surface). L-PRF (Intraspin system, Intra-Lock International) was placed in a split-mouth design to fill the macrogap between implant and socket walls on one side of the mandible. The contralateral side received implants without L-PRF. A mixed-model ANOVA (at ) evaluated the effect of implant surface, presence of L-PRF, and socket position (mesial or distal), individually or in combination on bone area fraction occupancy (BAFO). Results. BAFO values were significantly higher for the Ossean relative to the DAE surface on the larger mesial socket. The presence of L-PRF resulted in higher BAFO. The Ossean surface and L-PRF presence resulted in significantly higher BAFO. Conclusion. L-PRF and the micro-/nanometer scale textured surface resulted in increased bone formation around immediately placed implants.