miR-155 as a Biomarker in B-Cell Malignancies

Table 1

Cancer relevant target genes for miR-155 supported by experimental observations.

Target genes	Main effect of aberrant miR-155 expression	Reference
SHIP1	↑ PI3K/AKT activity	[22, 23]
	↑ B-cell proliferation
AID	↑ immunoglobulin diversification/class switch	[24]
PU.1	↑ immunoglobulin diversification/class switch	[25]
HGAL	↑ cell motility	[26]
C/EBPβ	↑ B-cell proliferation	[23]
SMAD5	↑ evasion of TGF-β’s growth inhibitory effects	[27]
FADD	↓ apoptosis	[28]
Ripk	↓ apoptosis	[28]
SOCS1	↑ STAT5 activation	[29]

AID, activation-induced cytidine deaminase; C/EBPβ, CCAAT/enhancer-binding protein β; FADD, Fas-Associated protein with Death Domain; HGAL, human germinal center-associated lymphoma; SHIP1, SH2 domain containing inositol 5′-phosphatase 1; SOCS1, suppressor of cytokine signaling protein 1.