Macrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome Analysis

Figure 3

Foam cells of macrophage origin in an atherosclerotic lesion of the human aorta (a, b). (a) CD68+ cells (brown), some of which display a typical foam cell appearance (arrows). Immunohistochemistry; peroxidase-anti-peroxidase (PAP) technique; counterstain with Mayer’s hematoxylin. (b) A large number of lipid inclusions (“lipid droplets”) (L) that fill practically all the cytoplasm in a foam cell in a human atherosclerotic plaque. Ly: lysosome; N: nucleus. TEM. Scale bars = 100 μm (a) and 2 μm (b).

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