Research Article
miR-375 and miR-205 Regulate the Invasion and Migration of Laryngeal Squamous Cell Carcinoma Synergistically via AKT-Mediated EMT
Table 2
Correlation between expression of miR-375 or miR-205 and clinicopathologic features of LSCCs.
| | Characteristics | | miR-375 ↑ | miR-375 ↓ | p | miR-205 ↑ | miR-205 ↓ | p |
| | All samples | (40) | 20 | 20 | | 20 | 20 | | | Age | | | | 0.53 | | | 0.20 | | ≤60 | (22) | 12 | 10 | | 9 | 13 | | | >60 | (18) | 8 | 10 | | 11 | 7 | | | pT status | | | | 0.02 | | | 0.33 | | Tis -T2 | (15) | 11 | 4 | | 9 | 6 | | | T3 -T4 | (25) | 9 | 16 | | 11 | 14 | | | pN status | | | | 0.33 | | | 0.74 | | N0 | (25) | 14 | 11 | | 12 | 13 | | | N > 0 | (15) | 6 | 9 | | 8 | 7 | | | Clinical UICC stage | | | | 0.01 | | | 0.29 | | Early stage (I-II) | (11) | 9 | 2 | | 7 | 4 | | | Advanced stage (III-IV) | (29) | 11 | 18 | | 13 | 16 | | | Pathological grade | | | | 0.14 | | | 1.00 | | G1 | (10) | 7 | 3 | | 5 | 5 | | | G2-G3 | (30) | 13 | 17 | | 15 | 15 | | | Anatomic site | | | | 0.08 | | | 0.01 | | Glottis+subglottis | (29) | 17 | 12 | | 11 | 18 | | | Supraglottis | (11) | 3 | 8 | | 9 | 2 | |
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All patients were staged according to the 2002 Union Form International Cancer Control (UICC) staging classification system for laryngeal cancer.
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