Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets

Figure 2

Th2 prevailing immune response in Sézary syndrome (SS)/erythrodermic MF (E-MF) and atopic dermatitis (AD). (a) SS/E-MF with malignant T cells circulating in the blood promote an immune response with production of Th2 phenotypic cytokines. Therefore suppressing the Th1 immune properties leads to impaired host immune response. (b) In the acute phase of atopic dermatitis naive T helper cells are primed in Th2 cells under the influence of activated skin resident DC which have the capacity of migrating to skin-draining lymph nodes. DC: dendritic cell, Eo: eosinophilic granulocyte.