Mouse Models in Prostate Cancer Translational Research: From Xenograft to PDX

Table 1

Prostatic mouse models of engraftment.

Type	Background strain	Year	Features	Disadvantages	Reference
Xenograft	Nude, SCID,; NOD-SCID,; NOG/NSG, RAG	1996–2006	High take rate, low costs, LNCaP, LNCaP-LN3, PC-3, PC-3M cell lines and human prostatic tissues implanted	Immune-compromised mice tested	[23–27]
Allograft	C57BL/6	1997–1994	High take rate, low costs, use of immune-competent mice; TRAMP-C1/2/3, PTEN-CaP8 cell lines implanted	Low translational potential	[31, 32, 38]
Allograft	BALBC/c	2004	High take rate, low costs, use of immune-competent mice; use of PNEC30 cell lines	Low translational potential; Neuroendocrine originated cells	[34]