|
| Name | Background strain | Year | Features | Disadvantages | Reference |
|
| C3(1)-Tag | FVB/N | 1994 | PHH (3 mths)
PCa (7–11 mths) | Sporadic metastases, aspecific breast cancer in female (12 wks) | [37] |
|
| TRAMP | C57BL/6 | 1994 | PHH (8 wks), PIN (18 wks)
Lymph. metastases (28 wks) | Neuroendocrine originated tumors | [38] |
|
| FG-Tag | C57BL/6 | 1996 | Accurate model of castration-resistant PCa | Aspecific adrenocortical tumors in 50% of female mice | [39] |
|
| LPB-Tag (LADY) | CD-1 | 1997 | Accurate model for all stages of PCa studies | Neuroendocrine originated foci in liver, lymph., and lung metastases | [40] |
|
| LPB-Tag/ARR2PB hepsin | C57BL/6JxCBA | 2004 | Increased migratory ability | Neuroendocrine originated cells forming liver metastases | [41] |
|
| Mt-PRL | C57BL/6JxCBA-f2 | 1997 | Appropriate model to study BPH | Rare PCa progression, no metastases | [42] |
|
| BK5-IGF1 |
FVB × ICR | 2000 | PIN (6 mths), PCa (9 mths) | Not metastases, off-target effects | [43] |
|
| PB-mAR | FVB | 2001 | Microinvasive HGPIN, useful in PCa studies about androgens | Rare metastases | [44] |
|
|
ARR2PB-Myc | FVB | 1999 | From PIN to PCa in 2 mths
Regression after castration (8 mths) | Not metastases observed | [45] |
|
| ARR2PB-FGFR1 | FVB | 2003 | Hyperproliferation and PIN | Failed in the later stages of disease | [46] |
|
| PB-Ras | FVB/N | 2004 | Did not progress further than PIN | Intestinal metaplasia
Thickened fibromuscular stroma | [47] |
|
| PB-Neu | C57BL/6JxCBA | 2006 | Similar to human acinar type | Low translational potential (rare cases of Neu alteration in human PCa) | [48] |
|
| ARR2PB-ERG | FVB | 2008 | PIN (12–14 wks) | Take rate of 38% | [49] |
|
