Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2016, Article ID 9781695, 8 pages
http://dx.doi.org/10.1155/2016/9781695
Review Article

Current Applications for the Use of Extracorporeal Carbon Dioxide Removal in Critically Ill Patients

Department of Adult Critical Care, Guy’s and St Thomas’ NHS Foundation Trust, King’s Health Partners, St Thomas’ Hospital, 1st Floor East Wing, Westminster Bridge Road, London SE1 7EH, UK

Received 1 December 2015; Accepted 20 January 2016

Academic Editor: Christophe Guervilly

Copyright © 2016 Luigi Camporota and Nicholas Barrett. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. S. Slutsky and V. M. Ranieri, “Ventilator-induced lung injury,” The New England Journal of Medicine, vol. 369, no. 22, pp. 2126–2136, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. P. Terragni, V. M. Ranieri, and L. Brazzi, “Novel approaches to minimize ventilator-induced lung injury,” Current Opinion in Critical Care, vol. 21, no. 1, pp. 20–25, 2015. View at Publisher · View at Google Scholar · View at Scopus
  3. L. Gattinoni, A. Pesenti, T. Kolobow, and G. Damia, “A new look at therapy of the adult respiratory distress syndrome: motionless lungs,” International Anesthesiology Clinics, vol. 21, no. 2, pp. 97–117, 1983. View at Google Scholar · View at Scopus
  4. C. Karagiannidis, K. A. Kampe, F. S. Sipmann et al., “Veno-venous extracorporeal CO2 removal for the treatment of severe respiratory acidosis: pathophysiological and technical considerations,” Critical Care, vol. 18, no. 3, article R124, 2014. View at Publisher · View at Google Scholar · View at Scopus
  5. P. Morimont, A. Batchinsky, and B. Lambermont, “Update on the role of extracorporeal CO2 removal as an adjunct to mechanical ventilation in ARDS,” Critical Care, vol. 19, no. 1, article 117, 2015. View at Publisher · View at Google Scholar
  6. P. Terragni, G. Maiolo, and V. M. Ranieri, “Role and potentials of low-flow CO2 removal system in mechanical ventilation,” Current Opinion in Critical Care, vol. 18, no. 1, pp. 93–98, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. M. E. Cove, G. MacLaren, W. J. Federspiel, and J. A. Kellum, “Bench to bedside review: extracorporeal carbon dioxide removal, past present and future,” Critical Care, vol. 16, no. 5, article 232, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. G. MacLaren, A. Combes, and R. H. Bartlett, “Contemporary extracorporeal membrane oxygenation for adult respiratory failure: life support in the new era,” Intensive Care Medicine, vol. 38, no. 2, pp. 210–220, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Pesenti, N. Patroniti, and R. Fumagalli, “Carbon dioxide dialysis will save the lung,” Critical Care Medicine, vol. 38, no. 10, supplement, pp. S549–S554, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Park, E. L. V. Costa, A. T. Maciel et al., “Determinants of Oxygen and Carbon Dioxide Transfer during Extracorporeal Membrane Oxygenation in an Experimental Model of Multiple Organ Dysfunction Syndrome,” PLoS ONE, vol. 8, no. 1, Article ID e54954, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. T. Müller, M. Lubnow, A. Philipp et al., “Extracorporeal pumpless interventional lung assist in clinical practice: determinants of efficacy,” European Respiratory Journal, vol. 33, no. 3, pp. 551–558, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. T. Bein, F. Weber, A. Philipp et al., “A new pumpless extracorporeal interventional lung assist in critical hypoxemia/hypercapnia,” Critical Care Medicine, vol. 34, no. 5, pp. 1372–1377, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Zimmermann, T. Bein, M. Arlt et al., “Pumpless extracorporeal interventional lung assist in patients with acute respiratory distress syndrome: a prospective pilot study,” Critical Care, vol. 13, no. 1, article R10, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. T. Bein, T. Muller, B. M. Graf et al., “Factors of tidal volume variation during augmented spontaneous ventilation in patients on extracorporeal carbon dioxide removal. A multivariate analysis,” Minerva Anestesiologica, vol. 81, no. 1, pp. 28–32, 2015. View at Google Scholar
  15. C. E. Ventetuolo and C. S. Muratore, “Extracorporeal life support in critically ill adults,” American Journal of Respiratory and Critical Care Medicine, vol. 190, no. 5, pp. 497–508, 2014. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Fitzgerald, J. Millar, B. Blackwood et al., “Extracorporeal carbon dioxide removal for patients with acute respiratory failure secondary to the acute respiratory distress syndrome: a systematic review,” Critical Care, vol. 18, no. 3, article 222, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. W. J. Kolff, H. T. Berk, M. ter Welle, L. A. van der Ley, E. C. van Dijk, and J. van Noordwijk, “The artificial kidney: a dialyser with a great area. 1944,” Journal of the American Society of Nephrology, vol. 8, no. 12, pp. 1959–1965, 1997. View at Google Scholar
  18. B. Flörchinger, A. Philipp, A. Klose et al., “Pumpless extracorporeal lung assist: a 10-year institutional experience,” Annals of Thoracic Surgery, vol. 86, no. 2, pp. 410–417, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. A. I. Batchinsky, B. S. Jordan, D. Regn et al., “Respiratory dialysis: reduction in dependence on mechanical ventilation by venovenous extracorporeal CO2 removal,” Critical Care Medicine, vol. 39, no. 6, pp. 1382–1387, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. P. Morimont, J. Guiot, T. Desaive et al., “Veno-venous extracorporeal CO2 removal improves pulmonary hemodynamics in a porcine ARDS model,” Acta Anaesthesiologica Scandinavica, vol. 59, no. 4, pp. 448–456, 2015. View at Publisher · View at Google Scholar
  21. S. Livigni, M. Maio, E. Ferretti et al., “Efficacy and safety of a low-flow veno-venous carbon dioxide removal device: results of an experimental study in adult sheep,” Critical Care, vol. 10, no. 5, article R151, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. P. D. Wearden, W. J. Federspiel, S. W. Morley et al., “Respiratory dialysis with an active-mixing extracorporeal carbon dioxide removal system in a chronic sheep study,” Intensive Care Medicine, vol. 38, no. 10, pp. 1705–1711, 2012. View at Publisher · View at Google Scholar
  23. A. Zanella, P. Mangili, M. Giani et al., “Extracorporeal carbon dioxide removal through ventilation of acidified dialysate: an experimental study,” Journal of Heart and Lung Transplantation, vol. 33, no. 5, pp. 536–541, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Zanella, P. Mangili, S. Redaelli et al., “Regional blood acidification enhances extracorporeal carbon dioxide removal: a 48-hour animal study,” Anesthesiology, vol. 120, no. 2, pp. 416–424, 2014. View at Publisher · View at Google Scholar · View at Scopus
  25. A. Pesenti, A. Pelizzola, D. Mascheroni et al., “Low frequency positive pressure ventilation with extracorporeal CO2 removal (LEPPV-ECCO2R) in acute respiratory failure (ARF): technique,” Transactions—American Society for Artificial Internal Organs, vol. 27, pp. 263–266, 1981. View at Google Scholar · View at Scopus
  26. T. Kolobow, L. Gattinoni, T. Tomlinson, and J. E. Pierce, “An alternative to breathing,” Journal of Thoracic and Cardiovascular Surgery, vol. 75, no. 2, pp. 261–266, 1978. View at Google Scholar · View at Scopus
  27. L. Gattinoni, A. Agostoni, A. Pesenti et al., “Treatment of acute respiratory failure with low-frequency positive-pressure ventilation and extracorporeal removal of CO2,” The Lancet, vol. 2, no. 8189, pp. 292–294, 1980. View at Publisher · View at Google Scholar · View at Scopus
  28. R. Marcolin, D. Mascheroni, A. Pesenti, M. Bombino, and L. Gattinoni, “Ventilatory impact of partial extracorporeal CO2 removal (PECOR) in ARF patients,” ASAIO Transactions, vol. 32, no. 1, pp. 508–510, 1986. View at Publisher · View at Google Scholar · View at Scopus
  29. A. Pesenti, G. P. Rossi, P. Pelosi, L. Brazzi, and L. Gattinoni, “Percutaneous extracorporeal CO2 removal in a patient with bullous emphysema with recurrent bilateral pneumothoraces and respiratory failure,” Anesthesiology, vol. 72, no. 3, pp. 571–573, 1990. View at Publisher · View at Google Scholar · View at Scopus
  30. L. Gattinoni, T. Kolobow, G. Damia, A. Agostoni, and A. Pesenti, “Extracorporeal carbon dioxide removal (ECCO2R): a new form of respiratory assistance,” International Journal of Artificial Organs, vol. 2, no. 4, pp. 183–185, 1979. View at Google Scholar · View at Scopus
  31. L. Gattinoni, T. Kolobow, T. Tomlinson et al., “Low-frequency positive pressure ventilation with extracorporeal carbon dioxide removal (LFPPV-ECCO2R): an experimental study,” Anesthesia and Analgesia, vol. 57, no. 4, pp. 470–477, 1978. View at Google Scholar · View at Scopus
  32. L. Gattinoni, T. Kolobow, T. Tomlinson, D. White, and J. Pierce, “Control of intermittent positive pressure breathing (IPPB) by extracorporeal removal of carbon dioxide,” British Journal of Anaesthesia, vol. 50, no. 8, pp. 753–758, 1978. View at Publisher · View at Google Scholar · View at Scopus
  33. L. Gattinoni, A. Pesenti, D. Mascheroni et al., “Low-frequency positive-pressure ventilation with extracorporeal CO2 removal in severe acute respiratory failure,” The Journal of the American Medical Association, vol. 256, no. 7, pp. 881–886, 1986. View at Publisher · View at Google Scholar · View at Scopus
  34. F. Brunet, M. Belghith, J.-P. Mira et al., “Extracorporeal carbon dioxide removal and low-frequency positive-pressure ventilation: improvement in arterial oxygenation with reduction of risk of pulmonary barotrauma in patients with adult respiratory distress syndrome,” Chest, vol. 104, no. 3, pp. 889–898, 1993. View at Publisher · View at Google Scholar · View at Scopus
  35. Health Quality Ontario, “Extracorporeal lung support technologies—bridge to recovery and bridge to lung transplantation in adult patients: an evidence-based analysis,” Ontario Health Technology Assessment Series, vol. 10, no. 5, pp. 1–47, 2010. View at Google Scholar
  36. E. D. Moloney and M. J. D. Griffiths, “Protective ventilation of patients with acute respiratory distress syndrome,” British Journal of Anaesthesia, vol. 92, no. 2, pp. 261–270, 2004. View at Publisher · View at Google Scholar · View at Scopus
  37. M. Britos, E. Smoot, K. D. Liu, B. T. Thompson, W. Checkley, and R. G. Brower, “The value of positive end-expiratory pressure and Fio2 criteria in the definition of the acute respiratory distress syndrome,” Critical Care Medicine, vol. 39, no. 9, pp. 2025–2030, 2011. View at Publisher · View at Google Scholar · View at Scopus
  38. L. Gattinoni, P. Caironi, M. Cressoni et al., “Lung recruitment in patients with the acute respiratory distress syndrome,” The New England Journal of Medicine, vol. 354, no. 17, pp. 1775–1786, 2006. View at Publisher · View at Google Scholar · View at Scopus
  39. T. J. Nuckton, J. A. Alonso, R. H. Kallet et al., “Pulmonary dead-space fraction as a risk factor for death in the acute respiratory distress syndrome,” The New England Journal of Medicine, vol. 346, no. 17, pp. 1281–1286, 2002. View at Publisher · View at Google Scholar · View at Scopus
  40. The ARDS Definition Task Force, “Acute respiratory distress syndrome: the Berlin definition,” The Journal of the American Medical Association, vol. 307, no. 23, pp. 2526–2533, 2012. View at Publisher · View at Google Scholar
  41. P. P. Terragni, G. Rosboch, A. Tealdi et al., “Tidal hyperinflation during low tidal volume ventilation in acute respiratory distress syndrome,” American Journal of Respiratory and Critical Care Medicine, vol. 175, no. 2, pp. 160–166, 2007. View at Publisher · View at Google Scholar · View at Scopus
  42. F. Brunet, J.-P. Mira, M. Belghith et al., “Extracorporeal carbon dioxide removal technique improves oxygenation without causing overinflation,” American Journal of Respiratory and Critical Care Medicine, vol. 149, no. 6, pp. 1557–1562, 1994. View at Publisher · View at Google Scholar · View at Scopus
  43. A. H. Morris, C. J. Wallace, R. L. Menlove et al., “Randomized clinical trial of pressure-controlled inverse ratio ventilation and extracorporeal CO2 removal for adult respiratory distress syndrome,” American Journal of Respiratory and Critical Care Medicine, vol. 149, no. 2, part 1, pp. 295–305, 1994. View at Publisher · View at Google Scholar · View at Scopus
  44. R. M. Muellenbach, M. Kredel, C. Wunder et al., “Arteriovenous extracorporeal lung assist as integral part of a multimodal treatment concept: A retrospective analysis of 22 patients with ARDS refractory to standard care,” European Journal of Anaesthesiology, vol. 25, no. 11, pp. 897–904, 2008. View at Publisher · View at Google Scholar · View at Scopus
  45. J. B. Zwischenberger, S. A. Conrad, S. K. Alpard, L. R. Grier, and A. Bidani, “Percutaneous extracorporeal arteriovenous CO2 removal for severe respiratory failure,” Annals of Thoracic Surgery, vol. 68, no. 1, pp. 181–187, 1999. View at Publisher · View at Google Scholar · View at Scopus
  46. P. P. Terragni, L. Del Sorbo, L. Mascia et al., “Tidal volume lower than 6 ml/kg enhances lung protection: role of extracorporeal carbon dioxide removal,” Anesthesiology, vol. 111, no. 4, pp. 826–835, 2009. View at Publisher · View at Google Scholar · View at Scopus
  47. T. Bein, S. Weber-Carstens, A. Goldmann et al., “Lower tidal volume strategy (3 ml/kg) combined with extracorporeal CO2 removal versus ‘conventional’ protective ventilation (6 ml/kg) in severe ARDS: the prospective randomized Xtravent-study,” Intensive Care Medicine, vol. 39, no. 5, pp. 847–856, 2013. View at Publisher · View at Google Scholar
  48. G. W. Hoo, N. Hakimian, and S. M. Santiago, “Hypercapnic respiratory failure in COPD patients: response to therapy,” Chest, vol. 117, no. 1, pp. 169–177, 2000. View at Publisher · View at Google Scholar · View at Scopus
  49. R. Menzies, W. Gibbons, and P. Goldberg, “Determinants of weaning and survival among patients with COPD who require mechanical ventilation for acute respiratory failure,” Chest, vol. 95, no. 2, pp. 398–405, 1989. View at Publisher · View at Google Scholar · View at Scopus
  50. D. Makris, B. Desrousseaux, E. Zakynthinos, A. Durocher, and S. Nseir, “The impact of COPD on ICU mortality in patients with ventilator-associated pneumonia,” Respiratory Medicine, vol. 105, no. 7, pp. 1022–1029, 2011. View at Publisher · View at Google Scholar · View at Scopus
  51. S. Nseir, C. Di Pompeo, S. Soubrier et al., “Impact of ventilator-associated pneumonia on outcome in patients with COPD,” Chest, vol. 128, no. 3, pp. 1650–1656, 2005. View at Publisher · View at Google Scholar · View at Scopus
  52. D. C. Abrams, K. Brenner, K. M. Burkart et al., “Pilot study of extracorporeal carbon dioxide removal to facilitate extubation and ambulation in exacerbations of chronic obstructive pulmonary disease,” Annals of the American Thoracic Society, vol. 10, no. 4, pp. 307–314, 2013. View at Publisher · View at Google Scholar · View at Scopus
  53. R. Roncon-Albuquerque, G. Carona, A. Neves et al., “Venovenous extracorporeal CO2 removal for early extubation in COPD exacerbations requiring invasive mechanical ventilation,” Intensive Care Medicine, vol. 40, no. 12, pp. 1969–1970, 2014. View at Publisher · View at Google Scholar · View at Scopus
  54. N. K. Burki, R. K. Mani, F. J. F. Herth et al., “A novel extracorporeal CO2 removal system: results of a pilot study of hypercapnic respiratory failure in patients with COPD,” Chest, vol. 143, no. 3, pp. 678–686, 2013. View at Publisher · View at Google Scholar · View at Scopus
  55. S. Cole, N. A. Barrett, G. Glover et al., “Extracorporeal carbon dioxide removal as an alternative to endotracheal intubation for non-invasive ventilation failure in acute exacerbation of COPD,” Journal of the Intensive Care Society, vol. 15, no. 4, pp. 344–346, 2014. View at Publisher · View at Google Scholar · View at Scopus
  56. S. Kluge, S. A. Braune, M. Engel et al., “Avoiding invasive mechanical ventilation by extracorporeal carbon dioxide removal in patients failing noninvasive ventilation,” Intensive Care Medicine, vol. 38, no. 10, pp. 1632–1639, 2012. View at Publisher · View at Google Scholar
  57. L. Del Sorbo, L. Pisani, C. Filippini et al., “Extracorporeal Co2 removal in hypercapnic patients at risk of noninvasive ventilation failure: a matched cohort study with historical control,” Critical Care Medicine, vol. 43, no. 1, pp. 120–127, 2015. View at Publisher · View at Google Scholar · View at Scopus
  58. R. Roncon-Albuquerque Jr. and D. Brodie, “Extracorporeal Co2 removal in severe chronic obstructive pulmonary disease exacerbations: a work in progress,” Critical Care Medicine, vol. 43, no. 3, pp. e102–e103, 2015. View at Publisher · View at Google Scholar
  59. K. Wiebe, J. Poeling, M. Arlt et al., “Thoracic surgical procedures supported by a pumpless interventional lung assist,” Annals of Thoracic Surgery, vol. 89, no. 6, pp. 1782–1788, 2010. View at Publisher · View at Google Scholar · View at Scopus
  60. P. Schellongowski, K. Riss, T. Staudinger et al., “Extracorporeal CO2 removal as bridge to lung transplantation in life-threatening hypercapnia,” Transplant International, vol. 28, no. 3, pp. 297–304, 2015. View at Publisher · View at Google Scholar · View at Scopus
  61. D. Ricci, M. Boffini, L. Del Sorbo et al., “The use of CO2 removal devices in patients awaiting lung transplantation: an initial experience,” Transplantation Proceedings, vol. 42, no. 4, pp. 1255–1258, 2010. View at Publisher · View at Google Scholar · View at Scopus