Protective Effect of an Antibody against Specific Extracellular Domain of TLR2 on Agonists-Driven Inflammatory and Allergic Response

Figure 5

Effects of anti-T20 on serum levels of TNF-α, IL-6, and LTC4 of PGN-challenged OVA allergic mice. The serum levels of (a) TNF-α, IL-6, and (b) LTC4 of OVA allergic mice (OVA model), OVA allergic plus PGN challenge mice (OVA model + PGN), OVA allergic plus PGN challenge plus anti-T20 mice (OVA model + PGN + r-anti-T20), OVA allergic plus PGN challenge plus rabbit IgG isotype control mice (OVA model + PGN + rIgG), and normal mice, as described in Section 2 (). Changes in rectal temperature and mortality were determined, respectively. , , and versus control.

(a)

(b)