Comparison of Three Chemotherapy Regimens in Elderly Patients with Diffuse Large B Cell Lymphoma: Experience at a Single National Reference Center in Mexico

Table 1

Comparison of demographic and clinical characteristics by treatment regimen.

	RCHOP	RChOP	RCOP	value
(%)	53 (100)	48 (100)	40 (100)
Mean age (range)	68 (66–73)	75 (71.5–79.7)	77.5 (74–81)	<
Female : male	31 : 22	30 : 18	24 : 16	0.9
Presence of
Cardiopathy	6 (11.32)	2 (4.17)	3 (7.5)	0.47
Mean FEVI ± SD	60.34 ± 5.87	61.27 ± 5.18	61.3 ± 5.67	0.649
Diabetes mellitus	6 (11.32)	12 (25)	13 (32.5)
Blood hypertension	14 (26.46)	13 (27.08)	14 (35)	0.62
Hepatitis (either HBV/HCV)	1 (1.89)	4 (8.33)	6 (15)	0.065
HIV	3 (5.66)	0	1 (2.5)	0.229
B symptoms	32 (60.38)	34 (70.83)	22 (55)	0.28
Bulky disease	25 (47.1)	27 (56.25)	16 (40)	0.31
ECOG	—	—	—
1	38 (71.7)	34 (70.83)	18 (45)
2	11 (20.75)	11 (22.92)	15 (37.5)
3	4 (7.55)	3 (6.25)	7 (17.5)
Extranodal sites	—	—	—
1	20 (37.74)	16 (33.3)	18 (45)
2	10 (18.87)	8 (16.67)	6 (15)	0.95
>3	6 (11.32)	6 (12.49)	4 (10)
None	17 (32.07)	18 (37.5)	12 (30)
Ann Arbor stage	—	—	—
I	3 (5.6)	6 (12.5)	5 (12.5)
II	11 (20.75)	10 (20.83)	7 (17.5)	0.85
III	16 (30.19)	10 (20.83)	10 (25)
IV	23 (43.4)	22 (45.83)	18 (45)
Elevated LDH	25 (47.17)	27 (56.25)	18 (45)	0.519
Age adjusted IPI	—	—	—
Low	10 (18.87)	9 (18.75)	5 (12.5)
Low-intermediate	12 (22.64)	10 (20.83)	9 (22.5)	0.856
High-intermediate	14 (26.42)	17 (35.42)	11 (27.5)
High	17 (32.08)	12 (25)	15 (37.5)
Histological subtype	—	—	—
Germinal center	29 (54.72)	14 (29.21)	16 (40)
Nongerminal center	17 (32.08)	26 (54.17)	17 (42.5)
Unclassifiable	0 (0)	5 (10.37)	5 (12.5)
Not available (not able to classify)	7 (13.2)	3 (6.25)	2 (15)

Kruskal-Wallis test.
Chi-square test.