BioMed Research International / 2016 / Article / Tab 3 / Clinical Study
Comparison of Three Chemotherapy Regimens in Elderly Patients with Diffuse Large B Cell Lymphoma: Experience at a Single National Reference Center in Mexico Table 3 Cox regression analysis of overall survival (OS).
Variable HR IC 95% valueUnivariate analysis Treatment RCHOP — RChOP 1.717 0.884–3.335 0.110 RCOP 1.844 0.928–3.664 0.081 ECOG 1 — 2 3.478 1.929–6.269 0.000 3 5.361 2.466–11.657 0.000 Infections None — Ambulatory treated 0.519 0.199–1.351 0.179 Required hospitalization 3.402 1.659–6.977 0.001 Febrile neutropenia 3.646 1.808–7.352 0.000 B symptoms None — Yes 2.267 1.213–4.236 0.010 Extranodal sites 1 1.703 0.842–3.443 0.138 2 2.393 1.088–5.260 0.030 3 or more 2.039 0.802–5.182 0.134 Bulky disease Yes 1.948 1.125–3.372 0.017 Cycles of treatment 0.642 0.573–0.720 0.000 HB mg/dL >13 10–12.9 1.431 0.777–2.636 0.249 8–10 2.543 0.774–8.355 0.124 <8 3.196 1.320–7.737 0.010 DHL High 2.012 1.157–3.496 0.013 Creatinine (mg/dL) 1.847 1.064–3.206 0.029 B2 microglobulin 1.196 1.061–1.350 0.003 Leucocytes 1.0001 1.00007–1.0002 0.000 Albumin (g/dL) 0.422 0.281–0.632 0.000 Age <75 — ≥75 1.06 0.624–1.82 0.812 Multivariate analysis Treatment RCHOP — RChOP 1.354 0.655–2.798 0.413 RCOP 1.045 0.425–2.568 0.922 ECOG 1 — 2 1.862 0.900–3.853 0.093 3 3.740 1.428–9.793 0.007 Infections None — Ambulatory treated 0.557 0.198–1.561 0.266 Required hospitalization 1.971 0.759–5.112 0.163 Febrile neutropenia 2.550 1.029–6.317 0.043 B symptoms None — Yes 2.377 1.150–4.912 0.019 Extranodal sites 1 1.590 0.689–2.667 0.276 2 1.946 0.752–5.035 0.170 3 or more 3.637 1.269–10.422 0.016 Bulky disease Yes 1.895 0.895–4.011 0.095 Cycles of treatment 0.600 0.513–0.702 0.000