BioMed Research International / 2016 / Article / Tab 4 / Clinical Study
Comparison of Three Chemotherapy Regimens in Elderly Patients with Diffuse Large B Cell Lymphoma: Experience at a Single National Reference Center in Mexico Table 4 Cox regression analysis of disease-free survival (DFS).
Variable HR IC 95% valueUnivariate analysis Treatment RCHOP — RChOP 1.380 0.442–4.302 0.578 RCOP 2.131 0.714–6.356 0.175 Infections None — Ambulatory treated 0.761 0.315–1.838 0.545 Required hospitalization 3.152 1.457–6.819 0.004 Febrile neutropenia 4.481 2.222–9.035 0.000 Hb mg/dL >13 — 10–12.9 1.555 0.854–2.831 0.148 8–10 1.669 0.398–6.999 0.484 <8 3.206 1.324–7.762 0.010 IPI Low — Low-intermediate 1.721 0.598–4.954 0.314 High-intermediate 2.737 1.020–7.342 0.045 High 2.705 1.009–7.252 0.048 Cycles of treatment 0.661 0.589–0.740 0.000 B symptoms Yes 2.099 1.140–3.863 0.017 Albumin (g/dL) 0.427 0.285–0.641 0.000 ECOG 2 2.328 1.282–4.227 0.005 3 3.900 1.767–8.605 0.001 LDH Increased 1.891 1.093–3.270 0.023 Creatinine (mg/dL) 1.965 1.130–3.415 0.017 Age — — — <75 years — — — ≥75 years 1.2 0.703–2.048 0.503 B2M microglobulin 1.211 1.077–1.361 0.001 Leucocytes 1.0001 1.00005–1.0002 0.002 Multivariate analysis Treatment RCHOP — RChOP 1.339 0.416–4.303 0.624 RCOP 11.967 2.781–51.483 0.001 Infections None — Ambulatory treated 0.848 0.327–2.198 0.736 Required hospitalization 2.459 0.970–6.237 0.058 Febrile neutropenia 2.650 1.135–6.189 0.024 HB mg/dL >13 10–12.9 2.008 1.053–3.827 0.034 8–10 2.121 0.468–9.606 0.329 <8 2.509 0.874–7.201 0.087 IPI Low — Low-intermediate 3.397 1.011–11.414 0.048 High-intermediate 9.612 2.952–31.293 0.000 High 9.411 2.946–30.069 0.000 Cycles of treatment 0.558 0.470–0.6625 0.000