Positive Effect of Higher Adult Body Mass Index on Overall Survival of Digestive System Cancers Except Pancreatic Cancer: A Systematic Review and Meta-Analysis
Table 2
Random-effect summary estimates of the hazard ratios (HRs) of the association of OS of DSC except pancreatic cancer with highest versus lowest BMI comparison and site-specific analysis of digestive system cancers.
Study
HR (95% CI)
I-squared
Region
North America
11
0.77 (0.65, 0.89)
32.5%
0.139
Other regions
13
0.84 (0.70, 0.99)
72.2%
<0.001
Number of patients
≤500
11
0.76 (0.55, 0.96)
81.4%
<0.001
>500
13
0.87 (0.76, 0.98)
33.5%
0.115
Study type
Retrospective
8
0.77 (0.53, 1.01)
79.8%
<0.001
Prospective
16
0.84 (0.72, 0.95)
49.3%
0.014
Adjusted for covariates
Yes
18
0.80 (0.68, 0.93)
54.2%
0.003
No
6
0.86 (0.70, 1.02)
67.7%
0.008
Adjusted for weight loss
Yes
4
0.78 (0.52, 1.05)
58.0%
0.068
No
20
0.83 (0.71, 0.94)
68.3%
<0.001
Adjusted for tumor grade
Yes
6
0.99 (0.70, 1.28)
51.9%
0.065
No
18
0.78 (0.67, 0.90)
74.2%
<0.001
Site-specific analysis of digestive system cancers
