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BioMed Research International
Volume 2017, Article ID 1056427, 10 pages
https://doi.org/10.1155/2017/1056427
Research Article

HIPK2 Overexpression and Its Prognostic Role in Human Papillomavirus-Positive Tonsillar Squamous Cell Carcinoma

1Department of Pathology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Gyeonggi-do 431-070, Republic of Korea
2Department of Pathology, Samsung Medical Center, Sungkyunkwan University College of Medicine, Seoul 135-710, Republic of Korea
3Department of Pathology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul 134-701, Republic of Korea
4Department of Otorhinolaryngology-Head and Neck Surgery, Ilsong Memorial Institute Head and Neck Cancer Center, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea

Correspondence should be addressed to Mi Jung Kwon; rk.ro.myllah@99knalum

Received 6 March 2017; Accepted 11 April 2017; Published 21 May 2017

Academic Editor: Claude Prigent

Copyright © 2017 Mi Jung Kwon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. M. Cohan, S. Popat, S. E. Kaplan, N. Rigual, T. Loree, and W. L. Hicks Jr., “Oropharyngeal cancer: current understanding and management,” Current Opinion in Otolaryngology and Head and Neck Surgery, vol. 17, no. 2, pp. 88–94, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. Y. C. Lim, B. S. Koo, J. S. Lee, J.-Y. Lim, and E. C. Choi, “Distributions of cervical lymph node metastases in oropharyngeal carcinoma: therapeutic implications for the N0 neck,” Laryngoscope, vol. 116, no. 7, pp. 1148–1152, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. O. Olaleye, R. Moorthy, O. Lyne, M. Black, D. Mitchell, and J. Wiseberg, “A 20-year retrospective study of tonsil cancer incidence and survival trends in South East England: 1987–2006,” Clinical Otolaryngology, vol. 36, no. 4, pp. 325–335, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. K.-W. Jung, S.-H. Yim, H.-J. Kong et al., “Cancer survival in Korea 1993-2002: A Population-Based Study,” Journal of Korean Medical Science, vol. 22, pp. S5–S10, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. K.-W. Jung, Y.-J. Won, H.-J. Kong, C.-M. Oh, H. G. Seo, and J.-S. Lee, “Prediction of cancer incidence and mortality in Korea, 2013,” Cancer Research and Treatment, vol. 45, no. 1, pp. 15–21, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. E. B. Stelow, V. Y. Jo, M. H. Stoler, and S. E. Mills, “Human papillomavirus-associated squamous cell carcinoma of the upper aerodigestive tract,” American Journal of Surgical Pathology, vol. 34, no. 7, pp. e15–e24, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Betiol, L. Villa, and L. Sichero, “Impact of HPV infection on the development of head and neck cancer,” Brazilian Journal of Medical and Biological Research, vol. 46, no. 3, pp. 217–226, 2013. View at Publisher · View at Google Scholar
  8. M. J. Kwon, D. H. Kim, H.-R. Park et al., “Frequent hepatocyte growth factor overexpression and low frequency of c-Met gene amplification in human papillomavirus-negative tonsillar squamous cell carcinoma and their prognostic significances,” Human Pathology, vol. 45, no. 7, pp. 1327–1338, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. G. Wei, S. Ku, G. K. Ma et al., “HIPK2 represses β-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 32, pp. 13040–13045, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. M. A. Al-Beiti, X. Lu, and X. S. Liu, “Correlation of HIPK2 expression with HPV infection and apoptosis in cervical cancer,” Zhonghua Zhong Liu Za Zhi, vol. 31, no. 6, pp. 434–437, 2009. View at Google Scholar · View at Scopus
  11. M. A. Al-Beiti and X. Lu, “Expression of HIPK2 in cervical cancer: correlation with clinicopathology and prognosis,” Australian and New Zealand Journal of Obstetrics and Gynaecology, vol. 48, no. 3, pp. 329–336, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. C. Rinaldo, A. Prodosmo, F. Siepi, and S. Soddu, “HIPK2: a multitalented partner for transcription factors in DNA damage response and development,” Biochemistry and Cell Biology, vol. 85, no. 4, pp. 411–418, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. M. A. Calzado, F. Renner, A. Roscic, and M. L. Schmitz, “HIPK2: a versatile switchboard regulating the transcription machinery and cell death,” Cell Cycle, vol. 6, no. 2, pp. 139–143, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Iacovelli, L. Ciuffini, C. Lazzari et al., “HIPK2 is involved in cell proliferation and its suppression promotes growth arrest independently of DNA damage,” Cell Proliferation, vol. 42, no. 3, pp. 373–384, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. H. zur Hausen, “Papillomaviruses and cancer: from basic studies to clinical application,” Nature Reviews Cancer, vol. 2, no. 5, pp. 342–350, 2002. View at Publisher · View at Google Scholar
  16. D. Muschik, I. Braspenning-Wesch, E. Stockfleth, F. Rösl, T. G. Hofmann, and I. Nindl, “Cutaneous HPV23 E6 prevents p53 phosphorylation through interaction with HIPK2,” PLoS ONE, vol. 6, no. 11, Article ID e27655, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. G. Dorazi, C. Rinaldo, and S. Soddu, “Updates on HIPK2: a resourceful oncosuppressor for clearing cancer,” Journal of Experimental and Clinical Cancer Research, vol. 31, no. 1, article 63, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. M. J. Kwon, S. K. Min, J. Seo et al., “HIPK2 expression in progression of cutaneous epithelial neoplasm,” International Journal of Dermatology, vol. 54, no. 3, pp. 347–354, 2015. View at Publisher · View at Google Scholar · View at Scopus
  19. G. D’Orazi, B. Cecchinelli, T. Bruno et al., “Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis,” Nature Cell Biology, vol. 4, no. 1, pp. 11–20, 2002. View at Publisher · View at Google Scholar · View at Scopus
  20. V. Di Stefano, C. Rinaldo, A. Sacchi, S. Soddu, and G. D'Orazi, “Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis,” Experimental Cell Research, vol. 293, no. 2, pp. 311–320, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. J. Wȩsierska-Ga̧dek, M. L. Schmitz, and C. Ranftler, “Roscovitine-activated HIP2 kinase induces phosphorylation of wt p53 at Ser-46 in human MCF-7 breast cancer cells,” Journal of Cellular Biochemistry, vol. 100, no. 4, pp. 865–874, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. M. J. Kwon, J. H. Kwon, E. S. Nam et al., “TWIST1 promoter methylation is associated with prognosis in tonsillar squamous cell carcinoma,” Human Pathology, vol. 44, no. 9, pp. 1722–1729, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. D. J. Lee, M. J. Kwon, E. S. Nam et al., “Histopathologic predictors of lymph node metastasis and prognosis in tonsillar squamous cell carcinoma,” Korean Journal of Pathology, vol. 47, no. 3, pp. 203–210, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. S. B. Edge, D. R. Byrd, C. C. Compton, A. G. Fritz, F. L. Greene, and A. I. Trotti, “Pharynx,” in AJCC Cancer Staging Manual, S. B. Edge, D. R. Byrd, C. C. Compton, A. G. Fritz, F. L. Greene, and A. I. Trotti, Eds., pp. 41–56, Springer, Chicago, Ill, USA, 2010. View at Google Scholar
  25. P. J. Slootweg and J. W. Eveson, “Tumours of the oral cavity and oropharynx,” in World Health Organization Classification of Tumours Pathology & Genetics Head and Neck Tumours, L. Barnes, J. W. Eveson, P. Reichart and, and D. Sidransky, Eds., pp. 166–175, IARC Press, Lyon, France, 2005. View at Google Scholar
  26. J.-J. Choi, C. Kim, and H. Park, “Peptide nucleic acid-based array for detecting and genotyping human papillomaviruses,” Journal of Clinical Microbiology, vol. 47, no. 6, pp. 1785–1790, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. H. C. Hafkamp, J. J. Manni, A. Haesevoets et al., “Marked differences in survival rate between smokers and nonsmokers with HPV 16-associated tonsillar carcinomas,” International Journal of Cancer, vol. 122, no. 12, pp. 2656–2664, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. G. D'Orazi, M. G. Sciulli, V. Di Stefano et al., “Homeodomain-interacting protein kinase-2 restrains cytosolic phospholipase A2-dependent prostaglandin E2 generation in human colorectal cancer cells,” Clinical Cancer Research, vol. 12, no. 3, part 1, pp. 735–741, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. L. Lavra, C. Rinaldo, A. Ulivieri et al., “The loss of the p53 activator HIPK2 is responsible for galectin-3 overexpression in well differentiated thyroid carcinomas,” PLoS ONE, vol. 6, no. 6, Article ID e20665, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. I. Soubeyran, I. Mahouche, A. Grigoletto et al., “Tissue microarray cytometry reveals positive impact of homeodomain interacting protein kinase 2 in colon cancer survival irrespective of p53 function,” American Journal of Pathology, vol. 178, no. 5, pp. 1986–1998, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. L. Nardinocchi, R. Puca, D. Givol, and G. D'Orazi, “HIPK2—a therapeutical target to be (re)activated for tumor suppression: Role in p53 activation and HIF-1α inhibition,” Cell Cycle, vol. 9, no. 7, pp. 1270–1275, 2010. View at Publisher · View at Google Scholar · View at Scopus
  32. Q. Zhang, Y. Yoshimatsu, J. Hildebrand, S. M. Frisch, and R. H. Goodman, “Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP,” Cell, vol. 115, no. 2, pp. 177–186, 2003. View at Publisher · View at Google Scholar · View at Scopus