Research Article
HIPK2 Overexpression and Its Prognostic Role in Human Papillomavirus-Positive Tonsillar Squamous Cell Carcinoma
Table 2
Association between HIPK2 expression and tonsil cancer patient characteristics.
| | Variable | Total | HIPK2 | | | Positive | Negative | | (%) | (%) | (%) |
| | Gender | | | | 0.406 | | Male | 68 (86.1) | 40 (88.9) | 28 (82.4) | | | Female | 11 (13.9) | 5 (11.1) | 6 (17.6) | | | Age (y) | | | | 0.079 | | ≤60 | 56 (70.9) | 28 (62.2) | 28 (82.4) | | | >60 | 23 (29.1) | 17 (37.8) | 6 (17.6) | | | Smoking (pack-years) | | | | 0.960 | | <20 | 23 (29.1) | 13 (28.9) | 10 (29.4) | | | ≥20 | 56 (70.9) | 32 (71.1) | 24 (70.6) | | | Alcohol (drinks/week) | | | | | | <14 | 32 (40.5) | 25 (55.6) | 7 (20.6) | | | ≥14 | 47 (59.5) | 20 (44.4) | 27 (79.4) | | | T classification | | | | 0.570 | | pT1-pT2 | 47 (59.5) | 28 (62.2) | 19 (55.9) | | | pT3-pT4 | 32 (40.5) | 17 (37.8) | 15 (44.1) | | | AJCC stage | | | | 0.861 | | I-II | 11 (13.9) | 6 (13.3) | 5 (14.7) | | | III-IV | 68 (86.1) | 39 (86.7) | 29 (85.3) | | | Depth of invasion | | | | 0.105 | | <2 cm | 61 (77.2) | 38 (84.4) | 23 (67.6) | | | ≥2 cm | 18 (22.8) | 7 (15.6) | 11 (32.4) | | | Tumor differentiation | | | | | | W/M | 53 (67.1) | 26 (57.8) | 27 (79.4) | | | Poorly | 26 (32.9) | 19 (42.2) | 7 (20.6) | | | Tumor-stromal border | | | | 0.495 | | Pushing | 42 (53.2) | 22 (48.9) | 20 (58.8) | | | Infiltrative | 37 (46.8) | 23 (51.1) | 14 (41.2) | | | Lymphatic invasion | | | | 0.095 | | Present | 63 (79.7) | 39 (86.7) | 24 (70.6) | | | Absent | 16 (20.3) | 6 (13.3) | 10 (29.4) | | | ILN status | | | | 0.375 | | Metastasis | 66 (83.5) | 36 (80.0) | 30 (88.2) | | | No metastasis | 13 (16.5) | 9 (20.0) | 4 (11.8) | | | CLN status | | | | 0.254 | | Metastasis | 14 (17.7) | 6 (13.3) | 8 (23.5) | | | No metastasis | 65 (82.3) | 39 (86.7) | 26 (76.5) | | | HPV status | | | | 1.000 | | Positive | 28 (35.4) | 16 (35.6) | 12 (35.3) | | | Negative | 51 (64.6) | 29 (64.4) | 22 (64.7) | | | p53 | | | | 0.133 | | Positive | 21 (26.6) | 15 (33.3) | 6 (17.6) | | | Negative | 58 (73.4) | 30 (66.7) | 28 (82.4) | |
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AJCC: American Joint Committee on Cancer; W: well differentiated; M: moderately differentiated; ILN: ipsilateral cervical lymph node; CLN: contralateral cervical lymph node metastasis; HPV: human papillomavirus. significant, value < 0.05.
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