Research Article
HIPK2 Overexpression and Its Prognostic Role in Human Papillomavirus-Positive Tonsillar Squamous Cell Carcinoma
Table 3
Multivariate analysis of overall survival and disease-free survival in TSCC patients.
| | | Overall survival | | Disease-free survival | | | Hazard ratio (95% CI) | Hazard ratio (95% CI) |
| | HIPK2 expression | | | | | | Negative versus positive | 2.958 (1.353–6.465) | | 3.004 (1.415–6.377) | | | HPV | | | | | | Negative versus positive | 0.324 (0.133–0.787) | | 0.358 (0.145–0.884) | | | Age (years) | | | | | | ≤60 versus >60 | 2.383 (1.068–5.314) | | 2.295 (1.011–5.206) | | | Smoking (pack-years) | | — | | 0.331 | | <20 versus ≥20 | — | | 1.573 (0.631–3.923) | | | pT category | | | | | | pT1 and pT2 versus pT3 and pT4 | 3.214 (1.478–6.989) | | 2.987 (1.349–6.613) | | | Differentiation | | 0.894 | | — | | W/M versus poorly | 1.049 (0.521–2.110) | | — | | | CLN | | | | | | No versus yes | 2.689 (1.164–6.214) | | 2.571 (1.136–5.820) | |
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TSCC: tonsillar squamous cell carcinoma; CI: confidence interval; HPV: human papillomavirus; W: well differentiated; M: moderately differentiated; CLN: contralateral cervical lymph node metastasis. significant, value < 0.05.
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