HIPK2 Overexpression and Its Prognostic Role in Human Papillomavirus-Positive Tonsillar Squamous Cell Carcinoma

Table 4

Univariate and multivariate analyses in the patients with postoperative radiation therapy affecting the overall and disease-free survival rates.

	⁢Overall survival			⁢Disease-free survival
	Univariate	Multivariate		Univariate	Multivariate
		HR (95% CI)			HR (95% CI)
HPV				0.148		0.227
Negative versus positive		0.220; (0.069–0.694)			0.560; (0.218–1.436)
HIPK2 expression	0.103		0.062
Negative versus positive		2.775; (0.951–8.095)			3.049; (1.133–8.206)
Age (years)
≤60 versus >60		4.362; (1.438–13.234)			4.698; (1.646–13.411)
pT category
pT1 and pT2 versus pT3 and pT4		3.925; (1.422–10.832)			2.883; (1.135–7.327)
CLN						0.118
No versus yes		3.645; (1.469–9.044)			1.961; (0.843–4.563)

HR: hazard ratio; CI: confidence interval; HPV: human papillomavirus; CLN: contralateral cervical lymph node metastasis. significant, value < 0.05.