Research Article
Association between Genetic Polymorphism and Risk of von Willebrand Disease in Pakistan
Table 4
Results for the genetic analysis on the basis of c.4975C>T, c.3445T>C, and c.7603C>T.
| | SNP | Genotypes/alleles | VWD | Control | Odds ratio (95% CI) | value | HWE | | | () |
| c.4975C>T
(%) | CC | 16 (38) | 96 (96) | 0.02 (0.007–0.832) | <0.0001 | 24.81 (0.000) | | CT | 16 (38) | 04 (04) | 14.7 (4.546–47.98) | | TT | 10 (24) | 00 (00) | Infinity (NaN-Infinity) | | C | 48 (58.5) | 196 (98) | Reference | <0.0001 | | T | 34 (41.5) | 04 (02) | 34.7 (11.75–102.5) |
| c.3445T>C
(%) | TT | 08 (19) | 97 (97) | 0.00 (0.001–0.029) | <0.0001 | 33 (0.000) | | TC | 19 (45) | 03 (03) | 26.71 (7.281–97.98) | | CC | 15 (36) | 00 (00) | Infinity (NaN-Infinity) | | T | 35 (41.6) | 197 (98.5) | Reference | <0.0001 | | C | 49 (58.4) | 03 (01.5) | 91.9 (27.14–311.3) |
| c.7603C>T
(%) | TT | 18 (43) | 97 (97) | 0.02 (0.00–0.08) | <0.0001 | 20.6 (0.000) | | TC | 16 (38) | 03 (03) | 21.5 (5.806–80.01) | | CC | 8 (19) | 00 (00) | Infinity (NaN-Infinity) | | T | 51 (60.8) | 197 (98.5) | Reference | <0.0001 | | C | 33 (39.2) | 03 (01.5) | 42.5 (12.52–144.1) |
|
|
association. to zero sample size in a group, the results show the failure in estimation and are mentioned here as “Infinity (NaN-Infinity).”
|
