Review Article

Preoperative Antihypertensive Medication in Relation to Postoperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery: A Meta-Analysis

Table 1

Characteristics of the 25 studies included in the meta-analysis.

StudyNumber of patients (AF/non-AF)CountryStudy designStyle of operationOR (95% CI)Definition of AFNOS points

Lee et al. 2014244/927KoreaCase-controlCABGNAPostoperative atrial fibrillation was defined as newly developed AF documented by electrocardiography (ECG) or continuous monitoring during the first 10 days after surgery8

Mariscalco and Engström 20082155/6279SwedenCase-controlCardiac surgeryNAThe AF definition included arrhythmia successfully treated as well as those persistent at discharge. The arrhythmia, as defined by physician assessment, was on the basis of a telemetry strip or from a 12-lead electrocardiogram recording7

Pivatto Jr. et al. 2014114/234BrazilCase-controlAVRNAAF consisted of any episode of supraventricular arrhythmia whose electrocardiography tracing showed “f” waves with varying morphology and amplitude as well as irregular ventricular rhythm4

Attaran et al. 20113292/8843United KingdomCase-controlCardiac surgeryNAAF, confirmed on electrocardiogram (ECG) for any length of time8

Girerd et al. 2009433/2214CanadaCase-controlCABGHypertension: OR = 0.89 (0.68 to 1.16)
Preoperative drugs:
beta blockers: OR = 1.03 (0.77 to 1.39)
ACEI and/or ARBs: OR = 1.26 (0.98 to 1.61)
Calcium channel-blockers: OR = 1.18 (0.92 to 1.52)
AF was defined as any sustained episode recorded during the postoperative hospital stay and requiring medical and/or electrical cardioversion6

Kinoshita et al. 2012159/646JapanCase-controlCABGHypertension: OR = 0.85 (0.58 to 1.18)
Preoperative drugs:
beta blockers: OR = 0.91 (0.61 to 1.41)
ACEI and/or ARBs: OR = 0.93 (0.60 to 1.44)
The endpoint was new-onset AF after surgery, which was diagnosed when there was an irregular cardiac rhythm without p waves lasting more than 60 min that required further administration of antiarrhythmics, cardioversion, or anticoagulation 8 therapy6

Villareal et al. 2004994/5481United StatesCase-controlCABGNAPostoperative AF was defined by the documentation of AF of any duration at any time in the postoperative period on a physician assessment, on the basis of a rhythm strip or 12-lead electrocardiogram recording8

Topal and Eren 201134/64TurkeyCase-controlCABGNANA4

Kinoshita et al. 201198/292JapanCase-controlCABGHypertension: OR = 0.92 (0.59 to 1.43)
Preoperative drugs:
beta blockers: OR = 0.79 (0.44 to 1.28)
ACEI and/or ARBs: OR = 0.90 (0.59 to 1.38)
The endpoint was new-onset AF after operation, which was diagnosed when there was an irregular cardiac rhythm without p waves lasting more than 60 minutes6

Saxena et al. 20125547/13950AustraliaCase-controlCABGNAPOAF was defined as evidence of new AF that required treatment by electrocardiography or continuous monitoring during the postoperative period7

Lapar et al. 20149255/40009United StatesCase-controlCardiac surgeryNANA7

Almassi et al. 2012551/1552United StatesCohortCABGHypertension: OR = 1.76 (1.23 to 2.50)AF was defined as any abnormal atrially originated irregular rhythm lasting more than 30 minutes7

Almassi et al. 19971143/2712United StatesCohortCardiac SurgeryNANA6

Mariscalco et al. 2008570/1262ItalyCohortCABGNANA7

Saxena et al. 2013725/1340AustraliaCohortAVRNAPOAF was defined as evidence of new AF that required treatment and was discovered by electrocardiography or continuous monitoring during the postoperative period.8

Leal et al. 201225/70BrazilCase-controlCABGNAWe defined AF occurrence as any AF episode requiring any type of medical treatment and/or lasting for more than 20 min within the hospital stay period6

Choi et al. 200966/249KoreaCohortCABGNANA4

Nardi et al. 201261/159ItalyCohortCABGHypertension: OR = 1.71 (0.89 to 2.26)
Preoperative drugs:
beta blockers: OR = 0.91 (0.33 to 20.46)
ACEI and/or ARBs: OR = 0.85 (0.33 to 20.17)
POAF, defined as any evidence of new AF by electrocardiography or continuous ECG monitoring, lasting at least 30 seconds during the postoperative period in our hospital6

Özlü et al. 201338/90TurkeyCohortCABGNAPresence of POAF lasting more than 5 min during hospitalization was detected by using continuous telemetry or 12-lead electrocardiography4

Çetin et al. 201262/210TurkeyCohortCABGHypertension: OR = 1.638 (0.728 to 3.687)
Preoperative drugs:
calcium channel-blockers: OR = 1.929 (0.627 to 5.935)
POAF was defined as any episode of atrial fibrillation within the hospital stay after CABG surgery6

Levy et al. 201228/30FranceCohortAVRNAPOAF combined paroxysmal and persistent AF. Paroxysmal AF was defined as self-terminating AF, usually within 48 hours. Persistent AF was defined as an AF episode that lasted longer than 7 days or required termination by cardioversion7

Mariscalco et al. 20144561/12701United KingdomCase-controlCardiac surgeryNAPOAF was documented on the basis of a rhythm strip or 12-lead ECG as previously described7

Aytemir et al. 199919/34TurkeyCohortCABGNANA5

Nisanoglu et al. 200791/335TurkeyCase-controlCABGHypertension: OR = 1.12 (0.70 to 1.79)AF was diagnosed if 12-lead ECG showed rapid oscillations or fibrillatory p waves that varied in size, shape, and timing, associated with irregular QRS complexes. For this study, postoperative7

Straus et al. 201064/76YugoslaviaCohortCABGNANA2

AF = atrial fibrillation; CI = confidence interval; NOS = Newcastle-Ottawa Scale; OR = odds ratio; NA = not available.