Inhibition of Fibrinolysis by Coagulation Factor XIII

Table 1

Summary of inhibitory effects of FXIII-mediated cross-links on fibrinolysis.

Type of cross-links	Inhibitory effect
Fibrin-fibrin cross-links
(i) chain dimers	None
(ii) chain polymers	Weak
(iii) High molecular weight chain polymers and/or chain multimers	Moderate
Fibrin-α2-antiplasmin cross-links
(i) In nonretracted fibrin clots	Weak
(ii) In retracted fibrin clots	Strong