A Simple but Accurate Method for Evaluating Drug-Resistance in Infectious HCVcc System

Table 1

Mutations in NS3/4A sequence after treatment with simeprevir.

Mutation	Frequency
D168V	59/60
R343Q	47/60
Y56H	28/60
A390T	3/60
G304A	2/60
V102A	1/60
K122N	1/60
R147K	1/60
S281C	1/60
Q309R	1/60
T312R	1/60
I354T	1/60
S398P	1/60
Y475C	1/60
G498E	1/60
M581T	1/60
K583E	1/60
V666A	1/60
Y56H/D168V	4/60
Y56H/T312R	1/60
Y56H/D168V/S281C	1/60
Y56H/D168V/R343Q	1/60
D168V/R343Q	7/60
D168V/A390T	1/60
D168V/V102A	1/60
D168V/G304A	1/60
D168V/Q309R/R343Q	1/60
D168V/I354T/S398P	1/60
D168V/R343Q/Y475C	1/60
D168V/R343Q/G498E	1/60
D168V/M581T/K583E	1/60
D168V/R343Q/K122N/V666A	1/60