New Antihyperglycemic Drugs and Heart Failure: Synopsis of Basic and Clinical Data

Figure 1

Timeline of already completed and still running cardiovascular safety trials. Green: DPP-4 inhibitors, orange: SGLT-2 inhibitors, and blue: GLP-1 receptor agonists. Name and number of planned included patients are given. All trials tested drugs versus placebo except the CAROLINA trail (linagliptin versus glimepiride).