MicroRNA as a Therapeutic Target in Cardiac Remodeling

Figure 3

MicroRNAs (miRNAs) in cardiac fibrosis pathways. Arrows colored in red indicate the functions of depression; arrows colored in green indicate the functions of activation. Abbreviations for mRNAs: β-MHC: beta myosin heavy chain; COL1: collagen, type 1; Col1α1: collagen, type 1 α 1; Col1α2: collagen, type 1 α 2; Col3α1: collagen, type 3 α 1; CTGF: connective tissue growth factor; IGF-1: insulin-like growth factor 1; IGF-1R: insulin-like growth factor 1 receptor; p38: Tumor protein p38; ROCK1: Rho associated coiled-coil containing protein kinase 1; SMAD3: SMAD family member 3; SMAD2: SMAD family member 2; SMAD7: SMAD family member 7; Spry1: sprouty homolog 1; TGF-β1: transforming growth factor β 1; TGF-βR1: transforming growth factor β receptor 1; TGFβRIII: transforming growth factor β receptor III; THRAP1: mediator complex subunit 13; ERK: extracellular regulated protein kinases; MAPK: mitogen-activated protein kinase; AG2R: anterior gradient-2.