BioMed Research International
Volume 2017 (2017), Article ID 1278436, 25 pages
https://doi.org/10.1155/2017/1278436
Review Article
MicroRNA as a Therapeutic Target in Cardiac Remodeling
Center for Developmental Cardiology, Institute for Translational Medicine, Qingdao University, Dengzhou Road 38, Qingdao 266021, China
Correspondence should be addressed to Kun Wang; moc.361@696kgnaw and Peifeng Li; nc.ude.udq@ilfiep
Received 3 May 2017; Revised 23 July 2017; Accepted 9 August 2017; Published 28 September 2017
Academic Editor: Kai Chen
Copyright © 2017 Chao Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- R. Dash, V. J. Kadambi, A. G. Schmidt et al., “Interactions between phospholamban and β-adrenergic drive may lead to cardiomyopathy and early mortality,” Circulation, vol. 103, no. 6, pp. 889–896, 2001. View at Publisher · View at Google Scholar · View at Scopus
- R. C. Lee, R. L. Feinbaum, and V. Ambros, “The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14,” Cell, vol. 75, no. 5, pp. 843–854, 1993. View at Publisher · View at Google Scholar · View at Scopus
- E. Lund, S. Güttinger, A. Calado, J. E. Dahlberg, and U. Kutay, “Nuclear export of microRNA precursors,” Science, vol. 303, no. 5654, pp. 95–98, 2004. View at Publisher · View at Google Scholar · View at Scopus
- Y. Lee, K. Jeon, J.-T. Lee, S. Kim, and V. N. Kim, “MicroRNA maturation: stepwise processing and subcellular localization,” The EMBO Journal, vol. 21, no. 17, pp. 4663–4670, 2002. View at Publisher · View at Google Scholar · View at Scopus
- T. A. McKinsey and E. N. Olson, “Toward transcriptional therapies for the failing heart: Chemical screens to modulate genes,” Journal of Clinical Investigation, vol. 115, no. 3, pp. 538–546, 2005. View at Publisher · View at Google Scholar · View at Scopus
- E. van Rooij, W. S. Marshall, and E. N. Olson, “Toward microRNA-based therapeutics for heart disease: the sense in antisense,” Circulation Research, vol. 103, no. 9, pp. 919–928, 2008. View at Publisher · View at Google Scholar · View at Scopus
- S. Ikeda, A. He, S. W. Kong et al., “MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genes,” Molecular and Cellular Biology, vol. 29, no. 8, pp. 2193–2204, 2009. View at Publisher · View at Google Scholar · View at Scopus
- G. P. Diniz, C. A. Lino, C. R. Moreno, N. Senger, and M. L. M. Barreto-Chaves, “MicroRNA-1 overexpression blunts cardiomyocyte hypertrophy elicited by thyroid hormone,” Journal of Cellular Physiology, 2017. View at Publisher · View at Google Scholar · View at Scopus
- M. He, Z. Yang, M. Abdellatif, and D. Sayed, “GTPase activating protein (SH3 domain) binding protein 1 regulates the processing of microRNA-1 during cardiac hypertrophy,” PLoS ONE, vol. 10, no. 12, Article ID e0145112, 2015. View at Publisher · View at Google Scholar · View at Scopus
- F. Varrone, B. Gargano, P. Carullo et al., “The circulating level of FABP3 is an indirect biomarker of microRNA-1,” Journal of the American College of Cardiology, vol. 61, no. 1, pp. 88–95, 2013. View at Publisher · View at Google Scholar · View at Scopus
- I. Karakikes, A. H. Chaanine, S. Kang et al., “Therapeutic cardiac-targeted delivery of miR-1 reverses pressure overload-induced cardiac hypertrophy and attenuates pathological remodeling.,” Journal of the American Heart Association, vol. 2, no. 2, p. e000078, 2013. View at Publisher · View at Google Scholar · View at Scopus
- H. Zhang, J. Wu, H. Dong, S. A. Khan, M.-L. Chu, and T. Tsuda, “Fibulin-2 deficiency attenuates angiotensin II-induced cardiac hypertrophy by reducing transforming growth factor-β signalling,” Clinical Science, vol. 126, no. 4, pp. 275–288, 2014. View at Publisher · View at Google Scholar · View at Scopus
- G. P. Diniz, C. A. Lino, E. C. Guedes, L. D. Nascimento Moreira, and M. L. M. Barreto-Chaves, “Cardiac microRNA-133 is down-regulated in thyroid hormone-mediated cardiac hypertrophy partially via Type 1 Angiotensin II receptor,” Basic Research in Cardiology, vol. 110, no. 5, article 49, 2015. View at Publisher · View at Google Scholar · View at Scopus
- A. Carè, D. Catalucci, F. Felicetti et al., “MicroRNA-133 controls cardiac hypertrophy,” Nature Medicine, vol. 13, no. 5, pp. 613–618, 2007. View at Publisher · View at Google Scholar · View at Scopus
- D. Wang, G. Zhai, Y. Ji, and H. Jing, “microRNA-10a targets T-box 5 to inhibit the development of cardiac hypertrophy,” International Heart Journal, vol. 58, no. 1, pp. 100–106, 2017. View at Publisher · View at Google Scholar · View at Scopus
- Y. Xiao, X. Zhang, S. Fan, G. Cui, and Z. Shen, “MicroRNA-497 inhibits cardiac hypertrophy by targeting Sirt4,” PLoS ONE, vol. 11, no. 12, Article ID e0168078, 2016. View at Publisher · View at Google Scholar · View at Scopus
- Y.-S. Wang, J. Zhou, K. Hong, X.-S. Cheng, and Y.-G. Li, “MicroRNA-223 displays a protective role against cardiomyocyte hypertrophy by targeting cardiac troponin I-interacting kinase,” Cellular Physiology and Biochemistry, vol. 35, no. 4, pp. 1546–1556, 2015. View at Publisher · View at Google Scholar · View at Scopus
- C. Wu, S. Dong, and Y. Li, “Effects of miRNA-455 on cardiac hypertrophy induced by pressure overload,” International Journal of Molecular Medicine, vol. 35, no. 4, pp. 893–900, 2015. View at Publisher · View at Google Scholar · View at Scopus
- J. Ganesan, D. Ramanujam, Y. Sassi et al., “MiR-378 controls cardiac hypertrophy by combined repression of mitogen-activated protein kinase pathway factors,” Circulation, vol. 127, no. 21, pp. 2097–2106, 2013. View at Publisher · View at Google Scholar · View at Scopus
- R. S. Nagalingam, N. R. Sundaresan, M. P. Gupta, D. L. Geenen, R. J. Solaro, and M. Gupta, “A cardiac-enriched microRNA, miR-378, blocks cardiac hypertrophy by targeting Ras signaling,” The Journal of Biological Chemistry, vol. 288, no. 16, pp. 11216–11232, 2013. View at Publisher · View at Google Scholar · View at Scopus
- R. Li, G. Yan, Q. Zhang et al., “miR-145 inhibits isoproterenol-induced cardiomyocyte hypertrophy by targeting the expression and localization of GATA6,” FEBS Letters, vol. 587, no. 12, pp. 1754–1761, 2013. View at Publisher · View at Google Scholar · View at Scopus
- Y. Duan, B. Zhou, H. Su, Y. Liu, and C. Du, “MiR-150 regulates high glucose-induced cardiomyocyte hypertrophy by targeting the transcriptional co-activator p300,” Experimental Cell Research, vol. 319, no. 3, pp. 173–184, 2013. View at Publisher · View at Google Scholar · View at Scopus
- Y. Yang, Y. Zhou, Z. Cao et al., “miR-155 functions downstream of angiotensin II receptor subtype 1 and calcineurin to regulate cardiac hypertrophy,” Experimental and Therapeutic Medicine, vol. 12, no. 3, pp. 1556–1562, 2016. View at Publisher · View at Google Scholar · View at Scopus
- A. Ucar, S. K. Gupta, J. Fiedler et al., “The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy,” Nature Communications, vol. 3, article 1078, 2012. View at Publisher · View at Google Scholar · View at Scopus
- K. Wang, Z.-Q. Lin, B. Long, J.-H. Li, J. Zhou, and P.-F. Li, “Cardiac hypertrophy is positively regulated by microRNA miR-23a,” Journal of Biological Chemistry, vol. 287, no. 1, pp. 589–599, 2012. View at Publisher · View at Google Scholar · View at Scopus
- M. Li, N. Wang, J. Zhang et al., “MicroRNA-29a-3p attenuates ET-1-induced hypertrophic responses in H9c2 cardiomyocytes,” Gene, vol. 585, no. 1, pp. 44–50, 2016. View at Publisher · View at Google Scholar · View at Scopus
- G. P. Diniz, A. P. Takano, and M. L. M. Barreto-Chaves, “MiRNA-208a and miRNA-208b are triggered in thyroid hormone-induced cardiac hypertrophy—role of type 1 Angiotensin II receptor (AT1R) on miRNA-208a/α-MHC modulation,” Molecular and Cellular Endocrinology, vol. 374, no. 1-2, pp. 117–124, 2013. View at Publisher · View at Google Scholar · View at Scopus
- E. van Rooij, L. B. Sutherland, X. Qi, J. A. Richardson, J. Hill, and E. N. Olson, “Control of stress-dependent cardiac growth and gene expression by a microRNA,” Science, vol. 316, no. 5824, pp. 575–579, 2007. View at Publisher · View at Google Scholar · View at Scopus
- Q. Bao, L. Chen, J. Li et al., “Role of microRNA-124 in cardiomyocyte hypertrophy inducedby angiotensin II,” Cellular and Molecular Biology, vol. 63, no. 4, pp. 23–27, 2017. View at Publisher · View at Google Scholar
- Q. Bao, M. Zhao, L. Chen et al., “MicroRNA-297 promotes cardiomyocyte hypertrophy via targeting sigma-1 receptor,” Life Sciences, vol. 175, pp. 1–10, 2017. View at Publisher · View at Google Scholar · View at Scopus
- J. Shi, Y. Bei, X. Kong et al., “miR-17-3p contributes to exercise-induced cardiac growth and protects against myocardial ischemia-reperfusion injury,” Theranostics, vol. 7, no. 3, pp. 664–676, 2017. View at Publisher · View at Google Scholar
- C. Bang, S. Batkai, and S. Dangwal, “Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy,” The Journal of Clinical Investigation, vol. 124, no. 5, pp. 2136–2146, 2014. View at Publisher · View at Google Scholar · View at Scopus
- H. Y. Seok, J. Chen, M. Kataoka et al., “Loss of MicroRNA-155 protects the heart from pathological cardiac hypertrophy,” Circulation Research, vol. 114, no. 10, pp. 1585–1595, 2014. View at Publisher · View at Google Scholar · View at Scopus
- X.-D. Xu, X.-W. Song, Q. Li, G.-K. Wang, Q. Jing, and Y.-W. Qin, “Attenuation of microRNA-22 derepressed PTEN to effectively protect rat cardiomyocytes from hypertrophy,” Journal of Cellular Physiology, vol. 227, no. 4, pp. 1391–1398, 2012. View at Publisher · View at Google Scholar · View at Scopus
- Z.-P. Huang, J. Chen, H. Y. Seok et al., “MicroRNA-22 regulates cardiac hypertrophy and remodeling in response to stress,” Circulation Research, vol. 112, no. 9, pp. 1234–1243, 2013. View at Publisher · View at Google Scholar · View at Scopus
- J. Yang, Y. Nie, F. Wang et al., “Reciprocal regulation of miR-23a and lysophosphatidic acid receptor signaling in cardiomyocyte hypertrophy,” Biochimica et Biophysica Acta—Molecular and Cell Biology of Lipids, vol. 1831, no. 8, pp. 1386–1394, 2013. View at Publisher · View at Google Scholar · View at Scopus
- X.-Y. You, J.-H. Huang, B. Liu, S.-J. Liu, Y. Zhong, and S.-M. Liu, “HMGA1 is a new target of miR-195 involving isoprenaline-induced cardiomyocyte hypertrophy,” Biochemistry, vol. 79, no. 6, pp. 538–544, 2014. View at Publisher · View at Google Scholar · View at Scopus
- D. Zheng, J. Ma, Y. Yu et al., “Silencing of miR-195 reduces diabetic cardiomyopathy in C57BL/6 mice,” Diabetologia, vol. 58, no. 8, pp. 1949–1958, 2015. View at Publisher · View at Google Scholar · View at Scopus
- D. W. Song, J. Y. Ryu, J. O. Kim, E. J. Kwon, and D. H. Kim, “The miR-19a/b family positively regulates cardiomyocyte hypertrophy by targeting atrogin-1 and MuRF-1,” Biochemical Journal, vol. 457, no. 1, pp. 151–162, 2014. View at Publisher · View at Google Scholar · View at Scopus
- J. Wang, Y. Song, Y. Zhang et al., “Cardiomyocyte overexpression of miR-27b induces cardiac hypertrophy and dysfunction in mice,” Cell Research, vol. 22, no. 3, pp. 516–527, 2012. View at Publisher · View at Google Scholar · View at Scopus
- C. Li, X. Li, X. Gao et al., “MicroRNA-328 as a regulator of cardiac hypertrophy,” International Journal of Cardiology, vol. 173, no. 2, pp. 268–276, 2014. View at Publisher · View at Google Scholar · View at Scopus
- J. O. Kim, D. W. Song, E. J. Kwon et al., “MiR-185 plays an anti-hypertrophic role in the heart via multiple targets in the calcium-signaling pathways,” PLoS ONE, vol. 10, no. 3, Article ID e0122509, 2015. View at Publisher · View at Google Scholar · View at Scopus
- L. Wei, M. Yuan, R. Zhou et al., “MicroRNA-101 inhibits rat cardiac hypertrophy by targeting Rab1a,” Journal of Cardiovascular Pharmacology, vol. 65, no. 4, pp. 357–363, 2015. View at Publisher · View at Google Scholar · View at Scopus
- R. L. Montgomery, T. G. Hullinger, H. M. Semus et al., “Therapeutic inhibition of miR-208a improves cardiac function and survival during heart failure,” Circulation, vol. 124, no. 14, pp. 1537–1547, 2011. View at Publisher · View at Google Scholar · View at Scopus
- A. Deb and E. Ubil, “Cardiac fibroblast in development and wound healing,” Journal of Molecular and Cellular Cardiology, vol. 70, pp. 47–55, 2014. View at Publisher · View at Google Scholar · View at Scopus
- S. N. Cilvik, J. I. Wang, K. J. Lavine et al., “Fibroblast growth factor receptor 1 signaling in adult cardiomyocytes increases contractility and results in a hypertrophic cardiomyopathy,” PLoS ONE, vol. 8, no. 12, Article ID e82979, 2013. View at Publisher · View at Google Scholar · View at Scopus
- Z. Pan, X. Sun, H. Shan et al., “MicroRNA-101 inhibited postinfarct cardiac fibrosis and improved left ventricular compliance via the FBJ osteosarcoma oncogene/transforming growth factor-β1 pathway,” Circulation, vol. 126, no. 7, pp. 840–850, 2012. View at Publisher · View at Google Scholar · View at Scopus
- X. Zhao, K. Wang, Y. Liao et al., “MicroRNA-101a inhibits cardiac fibrosis induced by hypoxia via targeting TGFβRI on cardiac fibroblasts,” Cellular Physiology and Biochemistry, vol. 35, no. 1, pp. 213–226, 2015. View at Publisher · View at Google Scholar · View at Scopus
- J. Beaumont, B. López, N. Hermida et al., “microRNA-122 down-regulation may play a role in severe myocardial fibrosis in human aortic stenosis through TGF-β1 up-regulation,” Clinical Science, vol. 126, no. 7, pp. 497–506, 2014. View at Publisher · View at Google Scholar · View at Scopus
- J. Wang, W. Huang, R. Xu et al., “MicroRNA-24 regulates cardiac fibrosis after myocardial infarction,” Journal of Cellular and Molecular Medicine, vol. 16, no. 9, pp. 2150–2160, 2012. View at Publisher · View at Google Scholar · View at Scopus
- R. Cheng, R. Dang, Y. Zhou, M. Ding, and H. Hua, “MicroRNA-98 inhibits TGF-β1-induced differentiation and collagen production of cardiac fibroblasts by targeting TGFBR1,” Human Cell, vol. 30, pp. 1–9, 2017. View at Publisher · View at Google Scholar · View at Scopus
- M. Zou, F. Wang, R. Gao et al., “Autophagy inhibition of hsa-miR-19a-3p/19b-3p by targeting TGF-β R II during TGF-β1-induced fibrogenesis in human cardiac fibroblasts,” Scientific Reports, vol. 6, Article ID 24747, 2016. View at Publisher · View at Google Scholar · View at Scopus
- T. G. Hullinger, R. L. Montgomery, and A. G. Seto, “Inhibition of miR-15 protects against cardiac ischemic injury,” Circulation Research, vol. 110, pp. 71–81, 2012. View at Publisher · View at Google Scholar
- E. R. Porrello, A. I. Mahmoud, E. Simpson et al., “Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family,” Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 1, pp. 187–192, 2013. View at Publisher · View at Google Scholar · View at Scopus
- R. S. Nagalingam, N. R. Sundaresan, M. Noor, M. P. Gupta, R. J. Solaro, and M. Gupta, “Deficiency of cardiomyocyte-specific MicroRNA-378 contributes to the development of cardiac fibrosis involving a transforming growth factor β (TGFβ1)-dependent paracrine mechanism,” Journal of Biological Chemistry, vol. 289, no. 39, pp. 27199–27214, 2014. View at Publisher · View at Google Scholar · View at Scopus
- H. Liang, C. Zhang, T. Ban et al., “A novel reciprocal loop between microRNA-21 and TGFβRIII is involved in cardiac fibrosis,” International Journal of Biochemistry and Cell Biology, vol. 44, no. 12, pp. 2152–2160, 2012. View at Publisher · View at Google Scholar · View at Scopus
- D. Zhang, Y. Cui, B. Li, X. Luo, B. Li, and Y. Tang, “miR-155 regulates high glucose-induced cardiac fibrosis via the TGF-β signaling pathway,” Molecular BioSystems, vol. 13, no. 1, pp. 215–224, 2017. View at Publisher · View at Google Scholar
- Y. Huang, Y. Qi, J.-Q. Du, and D.-F. Zhang, “MicroRNA-34a regulates cardiac fibrosis after myocardial infarction by targeting Smad4,” Expert Opinion on Therapeutic Targets, vol. 18, no. 12, pp. 1355–1365, 2014. View at Publisher · View at Google Scholar · View at Scopus
- R. F. Duisters, A. J. Tijsen, B. Schroen et al., “MiR-133 and miR-30 Regulate connective tissue growth factor: implications for a role of micrornas in myocardial matrix remodeling,” Circulation Research, vol. 104, no. 2, pp. 170–178, 2009. View at Publisher · View at Google Scholar · View at Scopus
- C. Wei, I.-K. Kim, S. Kumar et al., “NF-κB mediated miR-26a regulation in cardiac fibrosis,” Journal of Cellular Physiology, vol. 228, no. 7, pp. 1433–1442, 2013. View at Publisher · View at Google Scholar · View at Scopus
- G. M. Manzoni, G. Castelnuovo, and R. Proietti, “Assessment of psychosocial risk factors is missing in the 2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults,” Journal of the American College of Cardiology, vol. 57, no. 14, pp. 1569-1570, 2011. View at Publisher · View at Google Scholar · View at Scopus
- E. Van Rooij, L. B. Sutherland, J. E. Thatcher et al., “Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 35, pp. 13027–13032, 2008. View at Publisher · View at Google Scholar · View at Scopus
- K. Dawson, R. Wakili, B. Ördög et al., “MicroRNA29: a mechanistic contributor and potential biomarker in atrial fibrillation,” Circulation, vol. 127, no. 14, pp. 1466–1475, 2013. View at Publisher · View at Google Scholar · View at Scopus
- X. Li, N. Du, and Q. Zhang, “MicroRNA-30d regulates cardiomyocyte pyroptosis by directly targeting foxo3a in diabetic cardiomyopathy,” Cell Death and Disease, vol. 5, no. 10, Article ID e1479, 2014. View at Publisher · View at Google Scholar
- H. Seo, S. Lee, C. Y. Lee et al., “Exogenous mirna-146a enhances the therapeutic efficacy of human mesenchymal stem cells by increasing vascular endothelial growth factor secretion in the ischemia/reperfusion-injured heart,” Journal of Vascular Research, vol. 54, no. 2, pp. 100–108, 2017. View at Publisher · View at Google Scholar
- J. Y. Y. Ooi, B. C. Bernardo, and J. R. McMullen, “Therapeutic potential of targeting microRNAs to regulate cardiac fibrosis: MiR-433 a new fibrotic player,” Annals of Translational Medicine, vol. 4, no. 24, article no. 548, 2016. View at Publisher · View at Google Scholar · View at Scopus
- Y. Wang, M. Ouyang, Q. Wang, and Z. Jian, “MicroRNA-142-3p inhibits hypoxia/reoxygenation-induced apoptosis and fibrosis of cardiomyocytes by targeting high mobility group box 1,” International Journal of Molecular Medicine, vol. 38, no. 5, pp. 1377–1386, 2016. View at Publisher · View at Google Scholar · View at Scopus
- Y. Huang and J. Li, “MicroRNA208 family in cardiovascular diseases: therapeutic implication and potential biomarker,” Journal of Physiology and Biochemistry, vol. 71, no. 3, pp. 479–486, 2015. View at Publisher · View at Google Scholar
- K.-G. Shyu, B.-W. Wang, W.-P. Cheng, and H.-M. Lo, “MicroRNA-208a increases myocardial endoglin expression and myocardial fibrosis in acute myocardial infarction,” Canadian Journal of Cardiology, vol. 31, no. 5, pp. 679–690, 2015. View at Publisher · View at Google Scholar
- V. Nagpal, R. Rai, A. T. Place et al., “MiR-125b is critical for fibroblast-to-myofibroblast transition and cardiac fibrosis,” Circulation, vol. 133, no. 3, pp. 291–301, 2015. View at Publisher · View at Google Scholar
- K. Siddiquee, J. Hampton, S. Khan et al., “Apelin protects against angiotensin II-induced cardiovascular fibrosis and decreases plasminogen activator inhibitor type-1 production,” Journal of Hypertension, vol. 29, no. 4, pp. 724–731, 2011. View at Publisher · View at Google Scholar · View at Scopus
- R. Li, G. Yan, Q. Li et al., “MicroRNA-145 protects cardiomyocytes against hydrogen peroxide (H2O2)-induced apoptosis through targeting the mitochondria apoptotic pathway,” PLoS ONE, vol. 7, no. 9, Article ID e44907, 2012. View at Publisher · View at Google Scholar · View at Scopus
- X. Wang, X. Zhang, X.-P. Ren et al., “MicroRNA-494 targeting both proapoptotic and antiapoptotic proteins protects against ischemia/reperfusion-induced cardiac injury,” Circulation, vol. 122, no. 13, pp. 1308–1318, 2010. View at Publisher · View at Google Scholar · View at Scopus
- Y.-C. Zhao, “Effects of exercise training on myocardial mitochondrial miR-499-CaN-Drp-1 apoptotic pathway in mice,” Chinese Journal of Applied Physiology, vol. 31, no. 3, pp. 259–263, 2015. View at Google Scholar · View at Scopus
- J. Li, S. Donath, Y. Li, D. Qin, B. S. Prabhakar, and P. Li, “miR-30 regulates mitochondrial fission through targeting p53 and the dynamin-related protein-1 pathway,” PLoS Genetics, vol. 6, no. 1, Article ID e1000795, 2010. View at Publisher · View at Google Scholar · View at Scopus
- L. Roca-Alonso, L. Castellano, A. Mills et al., “Myocardial MiR-30 downregulation triggered by doxorubicin drives alterations in β-adrenergic signaling and enhances apoptosis,” Cell Death and Disease, vol. 6, no. 5, Article ID e1754, 2015. View at Publisher · View at Google Scholar · View at Scopus
- H. Wang, J. Li, H. Chi et al., “MicroRNA-181c targets Bcl-2 and regulates mitochondrial morphology in myocardial cells,” Journal of Cellular and Molecular Medicine, vol. 19, no. 9, pp. 2084–2097, 2015. View at Publisher · View at Google Scholar · View at Scopus
- X. Li, H. Wang, B. Yao, W. Xu, J. Chen, and X. Zhou, “LncRNA H19/miR-675 axis regulates cardiomyocyte apoptosis by targeting VDAC1 in diabetic cardiomyopathy,” Scientific Reports, vol. 6, Article ID 36340, 2016. View at Publisher · View at Google Scholar · View at Scopus
- J. O. Kim, E. J. Kwon, D. W. Song, J. S. Lee, and D. H. Kim, “miR-185 inhibits endoplasmic reticulum stress-induced apoptosis by targeting Na+/H+ exchanger-1 in the heart,” BMB Reports, vol. 49, no. 4, pp. 208–213, 2016. View at Publisher · View at Google Scholar · View at Scopus
- J. Fang, X.-W. Song, J. Tian et al., “Overexpression of microRNA-378 attenuates ischemia-induced apoptosis by inhibiting caspase-3 expression in cardiac myocytes,” Apoptosis, vol. 17, no. 4, pp. 410–423, 2012. View at Publisher · View at Google Scholar · View at Scopus
- S. Hu, M. Huang, Z. Li et al., “MicroRNA-210 as a novel therapy for treatment of ischemic heart disease,” Circulation, vol. 122, no. 11, pp. S124–S131, 2010. View at Publisher · View at Google Scholar · View at Scopus
- R. K. Mutharasan, V. Nagpal, Y. Ichikawa, and H. Ardehali, “microRNA-210 is upregulated in hypoxic cardiomyocytes through Akt- and p53-dependent pathways and exerts cytoprotective effects,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 301, no. 4, pp. H1519–H1530, 2011. View at Publisher · View at Google Scholar · View at Scopus
- J. Xiao, Y. Pan, X. H. Li et al., “Cardiac progenitor cell-derived exosomes prevent cardiomyocytes apoptosis through exosomal miR-21 by targeting PDCD4,” Cell Death & Disease, vol. 7, no. 6, Article ID e2277, 2016. View at Publisher · View at Google Scholar
- X. Zheng, X. Hu, T. Ge et al., “MicroRNA-328 is involved in the effect of selenium on hydrogen peroxide-induced injury in H9c2 cells,” Journal of Biochemical and Molecular Toxicology, vol. 31, no. 8, p. e21920, 2017. View at Publisher · View at Google Scholar
- L. Qian, L. W. Van Laake, Y. Huang, S. Liu, M. F. Wendland, and D. Srivastava, “miR-24 inhibits apoptosis and represses Bim in mouse cardiomyocytes,” The Journal of Experimental Medicine, vol. 208, no. 3, pp. 549–560, 2011. View at Publisher · View at Google Scholar · View at Scopus
- D. F. Li, J. Tian, X. Guo et al., “Induction of microrna-24 by hif-1 protects against ischemic injury in rat cardiomyocytes,” Physiological Research, vol. 61, pp. 555–565, 2012. View at Google Scholar
- A. B. Aurora, A. I. Mahmoud, X. Luo et al., “MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca2+ overload and cell death,” Journal of Clinical Investigation, vol. 122, no. 4, pp. 1222–1232, 2012. View at Publisher · View at Google Scholar · View at Scopus
- X. Diao and S. Sun, “PMicroRNA-124a regulates LPS-induced septic cardiac dysfunction by targeting STX2,” Biotechnology Letters, vol. 39, no. 9, pp. 1335–1342, 2017. View at Publisher · View at Google Scholar
- S. Rane, M. He, D. Sayed et al., “Downregulation of MiR-199a derepresses hypoxia-inducible factor-1α and sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes,” Circulation Research, vol. 104, no. 7, pp. 879–886, 2009. View at Publisher · View at Google Scholar · View at Scopus
- X. Meng, Y. Ji, Z. Wan et al., “Inhibition of miR-363 protects cardiomyocytes against hypoxia-induced apoptosis through regulation of Notch signaling,” Biomedicine and Pharmacotherapy, vol. 90, pp. 509–516, 2017. View at Publisher · View at Google Scholar · View at Scopus
- J.-W. Li, S.-Y. He, Z.-Z. Feng et al., “MicroRNA-146b inhibition augments hypoxia-induced cardiomyocyte apoptosis,” Molecular Medicine Reports, vol. 12, no. 5, pp. 6903–6910, 2015. View at Publisher · View at Google Scholar · View at Scopus
- X. Wang, T. Ha, Y. Hu et al., “MicroRNA-214 protects against hypoxia/reoxygenation induced cell damage and myocardial ischemia/reperfusion injury via suppression of PTEN and Bim1 expression,” Oncotarget, vol. 7, no. 52, pp. 86926–86936, 2016. View at Publisher · View at Google Scholar · View at Scopus
- Z. Chen, S. Zhang, C. Guo, J. Li, and W. Sang, “Downregulation of miR-200c protects cardiomyocytes from hypoxia-induced apoptosis by targeting GATA-4,” International Journal of Molecular Medicine, vol. 39, no. 6, pp. 1589–1596, 2017. View at Publisher · View at Google Scholar
- B. Zhang, M. Zhou, C. Li et al., “MicroRNA-92a inhibition attenuates hypoxia/reoxygenation-induced myocardiocyte apoptosis by targeting Smad7,” PLoS ONE, vol. 9, no. 6, Article ID e100298, 2014. View at Publisher · View at Google Scholar · View at Scopus
- C.-H. Yeh, T.-P. Chen, Y.-C. Wang, Y.-M. Lin, and S.-W. Fang, “MicroRNA-27a regulates cardiomyocytic apoptosis during cardioplegia-induced cardiac arrest by targeting interleukin 10-related pathways,” Shock, vol. 38, no. 6, pp. 607–614, 2012. View at Publisher · View at Google Scholar · View at Scopus
- H. Xiong, T. Luo, W. He et al., “Up-regulation of miR-138 inhibits hypoxia-induced cardiomyocyte apoptosis via down-regulating lipocalin-2 expression,” Experimental Biology and Medicine, vol. 241, no. 1, pp. 25–30, 2016. View at Publisher · View at Google Scholar · View at Scopus
- S. He, P. Liu, Z. Jian et al., “MiR-138 protects cardiomyocytes from hypoxia-induced apoptosis via MLK3/JNK/c-jun pathway,” Biochemical and Biophysical Research Communications, vol. 441, no. 4, pp. 763–769, 2013. View at Publisher · View at Google Scholar · View at Scopus
- Y. Ye, Z. Hu, Y. Lin, C. Zhang, and J. R. Perez-Polo, “Downregulation of microRNA-29 by antisense inhibitors and a PPAR-γ agonist protects against myocardial ischaemia–reperfusion injury,” Cardiovascular Research, vol. 87, no. 3, pp. 535–544, 2010. View at Publisher · View at Google Scholar
- Z. W. Zhang, H. Li, S. S. Chen, Y. Li, Z. Y. Cui, and J. Ma, “MicroRNA-122 regulates caspase-8 and promotes the apoptosis of mouse cardiomyocytes,” Brazilian Journal of Medical and Biological Research, vol. 50, no. 2, p. e5760, 2017. View at Publisher · View at Google Scholar
- I. Knezevic, A. Patel, N. R. Sundaresan et al., “A novel cardiomyocyte-enriched MicroRNA, miR-378, targets insulin-like growth factor 1 receptor: implications in postnatal cardiac remodeling and cell survival,” The Journal of Biological Chemistry, vol. 287, no. 16, pp. 12913–12926, 2012. View at Publisher · View at Google Scholar · View at Scopus
- R.-Y. Zhu, D. Zhang, H.-D. Zou, X.-S. Zuo, Q.-S. Zhou, and H. Huang, “MiR-28 inhibits cardiomyocyte survival through suppressing PDK1/Akt/mTOR signaling,” In Vitro Cellular and Developmental Biology—Animal, vol. 52, no. 10, pp. 1020–1025, 2016. View at Publisher · View at Google Scholar · View at Scopus
- Z. Pan, X. Sun, J. Ren et al., “miR-1 exacerbates cardiac ischemia-reperfusion injury in mouse models,” PLoS ONE, vol. 7, no. 11, Article ID e50515, 2012. View at Publisher · View at Google Scholar · View at Scopus
- H. Zhu, Y. Yang, Y. Wang, J. Li, P. W. Schiller, and T. Peng, “MicroRNA-195 promotes palmitate-induced apoptosis in cardiomyocytes by down-regulating Sirt1,” Cardiovascular Research, vol. 92, no. 1, pp. 75–84, 2011. View at Publisher · View at Google Scholar · View at Scopus
- E. R. Porrello, B. A. Johnson, A. B. Aurora et al., “MiR-15 family regulates postnatal mitotic arrest of cardiomyocytes,” Circulation Research, vol. 109, no. 6, pp. 670–679, 2011. View at Publisher · View at Google Scholar · View at Scopus
- S. P. Li, B. Liu, B. Song, C. X. Wang, and Y. C. Zhou, “Mir-28 promotes cardiac ischemia by targeting mitochondrial aldehyde dehydrogenase 2 (aldh2) in mus musculus cardiac myocytes,” European Review for Medical and Pharmacological Sciences, vol. 19, pp. 752–758, 2015. View at Google Scholar
- F. Fan, A. Sun, H. Zhao et al., “MicroRNA-34a promotes cardiomyocyte apoptosis post myocardial infarction through down-regulating aldehyde dehydrogenase 2,” Current Pharmaceutical Design, vol. 19, no. 27, pp. 4865–4873, 2013. View at Publisher · View at Google Scholar · View at Scopus
- R. A. Boon, K. Iekushi, and S. Lechner, “MicroRNA-34a regulates cardiac ageing and function,” Nature, vol. 494, no. 7439, pp. 107–110, 2013. View at Publisher · View at Google Scholar · View at Scopus
- H. Wu, F. Wang, S. Hu et al., “MiR-20a and miR-106b negatively regulate autophagy induced by leucine deprivation via suppression of ULK1 expression in C2C12 myoblasts,” Cellular Signalling, vol. 24, no. 11, pp. 2179–2186, 2012. View at Publisher · View at Google Scholar · View at Scopus
- Z. Wang, N. Wang, P. Liu et al., “MicroRNA-25 regulates chemoresistance-associated autophagy in breast cancer cells, a process modulated by the natural autophagy inducer isoliquiritigenin,” Oncotarget, vol. 5, no. 16, pp. 7013–7026, 2014. View at Publisher · View at Google Scholar · View at Scopus
- X. Duan, T. Zhang, S. Ding et al., “microRNA-17-5p modulates bacille calmette-guerin growth in RAW264.7 cells by targeting ULK1,” PLoS ONE, vol. 10, no. 9, Article ID e0138011., 2015. View at Publisher · View at Google Scholar · View at Scopus
- Y. Huang, A. Y. Chuang, and E. A. Ratovitski, “Phospho-ΔNp63α/miR-885-3p axis in tumor cell life and cell death upon cisplatin exposure,” Cell Cycle, vol. 10, no. 22, pp. 3938–3947, 2011. View at Publisher · View at Google Scholar · View at Scopus
- D. Z. John Clotaire, B. Zhang, N. Wei et al., “MiR-26b inhibits autophagy by targeting ULK2 in prostate cancer cells,” Biochemical and Biophysical Research Communications, vol. 472, no. 1, pp. 194–200, 2016. View at Publisher · View at Google Scholar · View at Scopus
- B. Zheng, H. Zhu, D. Gu et al., “MiRNA-30a-mediated autophagy inhibition sensitizes renal cell carcinoma cells to sorafenib,” Biochemical and Biophysical Research Communications, vol. 459, no. 2, pp. 234–239, 2015. View at Publisher · View at Google Scholar · View at Scopus
- R. Xu, S. Liu, H. Hong Chen, and L. Lao, “MicroRNA-30a downregulation contributes to chemoresistance of osteosarcoma cells through activating Beclin-1-mediated autophagy,” Oncology Reports, vol. 35, no. 3, pp. 1757–1763, 2016. View at Publisher · View at Google Scholar · View at Scopus
- B. Wang, Y. Zhong, D. Huang, and J. Li, “Macrophage autophagy regulated by miR-384-5p-mediated control of Beclin-1 plays a role in the development of atherosclerosis,” American Journal of Translational Research, vol. 8, no. 2, pp. 606–614, 2016. View at Google Scholar · View at Scopus
- S. Tan, H. Shi, M. Ba et al., “MiR-409-3p sensitizes colon cancer cells to oxaliplatin by inhibiting Beclin-1-mediated autophagy,” International Journal of Molecular Medicine, vol. 37, no. 4, pp. 1030–1038, 2016. View at Publisher · View at Google Scholar · View at Scopus
- X. Zhang, H. Shi, S. Lin, M. Ba, and S. Cui, “MicroRNA-216a enhances the radiosensitivity of pancreatic cancer cells by inhibiting beclin-1-mediated autophagy,” Oncology Reports, vol. 34, no. 3, pp. 1557–1564, 2015. View at Publisher · View at Google Scholar
- Y. Huang, R. Guerrero-Preston, and E. A. Ratovitski, “Phospho-ΔNp63α-dependent regulation of autophagic signaling through transcription and micro-RNA modulation,” Cell Cycle, vol. 11, no. 6, pp. 1247–1259, 2012. View at Publisher · View at Google Scholar · View at Scopus
- K. A. Tekirdag, G. Korkmaz, D. G. Ozturk, R. Agami, and D. Gozuacik, “MIR181A regulates starvation-and rapamycininduced autophagy through targeting of ATG5,” Autophagy, vol. 9, no. 3, pp. 374–385, 2013. View at Publisher · View at Google Scholar · View at Scopus
- X. Guo, H. Xue, X. Guo et al., “MiR224-3p inhibits hypoxia-induced autophagy by targeting autophagy-related genes in human glioblastoma cells,” Oncotarget, vol. 6, no. 39, pp. 41620–41637, 2015. View at Publisher · View at Google Scholar · View at Scopus
- Y. Yu, L. Yang, M. Zhao et al., “Targeting microRNA-30a-mediated autophagy enhances imatinib activity against human chronic myeloid leukemia cells,” Leukemia, vol. 26, no. 8, pp. 1752–1760, 2012. View at Publisher · View at Google Scholar · View at Scopus
- X. Yang, X. Zhong, J. L. Tanyi et al., “mir-30d regulates multiple genes in the autophagy pathway and impairs autophagy process in human cancer cells,” Biochemical and Biophysical Research Communications, vol. 431, no. 3, pp. 617–622, 2013. View at Publisher · View at Google Scholar · View at Scopus
- Y. Chang, W. Yan, X. He et al., “MiR-375 inhibits autophagy and reduces viability of hepatocellular carcinoma cells under hypoxic conditions,” Gastroenterology, vol. 143, no. 1, pp. 177–187, 2012. View at Publisher · View at Google Scholar · View at Scopus
- S. Zhao, D. Yao, J. Chen, N. Ding, and F. Ren, “MiR-20a promotes cervical cancer proliferation and metastasis in vitro and in vivo,” PLoS ONE, vol. 10, no. 3, Article ID e0120905, 2015. View at Publisher · View at Google Scholar · View at Scopus
- Y. Zeng, G. Huo, Y. Mo, W. Wang, and H. Chen, “MIR137 Regulates Starvation-Induced Autophagy by Targeting ATG7,” Journal of Molecular Neuroscience, vol. 56, no. 4, pp. 815–821, 2015. View at Publisher · View at Google Scholar · View at Scopus
- K. Wang, C.-Y. Liu, L.-Y. Zhou et al., “APF lncRNA regulates autophagy and myocardial infarction by targeting miR-188-3p,” Nature Communications, vol. 6, article 6779, 2015. View at Publisher · View at Google Scholar · View at Scopus
- N. Xu, J. Zhang, C. Shen et al., “Cisplatin-induced downregulation of miR-199a-5p increases drug resistance by activating autophagy in HCC cell,” Biochemical and Biophysical Research Communications, vol. 423, no. 4, pp. 826–831, 2012. View at Publisher · View at Google Scholar · View at Scopus
- G. Korkmaz, C. le Sage, K. A. Tekirdag, R. Agami, and D. Gozuacik, “miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1,” Autophagy, vol. 8, no. 2, pp. 165–176, 2012. View at Publisher · View at Google Scholar · View at Scopus
- G. Korkmaz, K. A. Tekirdag, D. G. Ozturk, A. Kosar, O. U. Sezerman, and D. Gozuacik, “MIR376A is a regulator of starvation-induced autophagy,” PLoS ONE, vol. 8, no. 12, Article ID e82556, 2013. View at Publisher · View at Google Scholar · View at Scopus
- L. B. Frankel, J. Wen, M. Lees et al., “microRNA-101 is a potent inhibitor of autophagy,” The EMBO Journal, vol. 30, no. 22, pp. 4628–4641, 2011. View at Publisher · View at Google Scholar · View at Scopus
- G. Wang, T. Zhao, L. Wang et al., “Studying different binding and intracellular delivery efficiency of ssdna single-walled carbon nanotubes and their effects on lc3-related autophagy in renal mesangial cells via mirna-382,” ACS Applied Materials and Interfaces, vol. 7, no. 46, pp. 25733–25740, 2015. View at Publisher · View at Google Scholar · View at Scopus
- Q. Jiang, Y. Han, H. Gao, R. Tian, P. Li, and C. Wang, “Ursolic acid induced anti-proliferation effects in rat primary vascular smooth muscle cells is associated with inhibition of microRNA-21 and subsequent PTEN/PI3K,” European Journal of Pharmacology, vol. 781, pp. 69–75, 2016. View at Publisher · View at Google Scholar · View at Scopus
- V. Kovaleva, R. Mora, Y. J. Park et al., “miRNA-130a targets ATG2B and DICER1 to inhibit autophagy and trigger killing of chronic lymphocytic leukemia cells,” Cancer Research, vol. 72, no. 7, pp. 1763–1772, 2012. View at Publisher · View at Google Scholar · View at Scopus
- Y. Jin, J. Wei, Z. Ma et al., “MiR-143 inhibits cell proliferation by targeting autophagy-related 2B in non-small cell lung cancer H1299 cells,” Molecular Medicine Reports, vol. 11, no. 1, pp. 571–576, 2015. View at Publisher · View at Google Scholar · View at Scopus
- J. Huang, W. Sun, H. Huang et al., “MiR-34a modulates angiotensin II-induced myocardial hypertrophy by direct inhibition of ATG9A Expression and Autophagic Activity,” PLoS ONE, vol. 9, no. 4, Article ID e94382, 2014. View at Publisher · View at Google Scholar · View at Scopus
- H. Zhai, B. Song, X. Xu, W. Zhu, and J. Ju, “Inhibition of autophagy and tumor growth in colon cancer by miR-502,” Oncogene, vol. 32, no. 12, pp. 1570–1579, 2013. View at Publisher · View at Google Scholar · View at Scopus
- R. Wang, Z.-X. Wang, J.-S. Yang, X. Pan, W. De, and L.-B. Chen, “MicroRNA-451 functions as a tumor suppressor in human non-small cell lung cancer by targeting ras-related protein 14 (RAB14),” Oncogene, vol. 30, no. 23, pp. 2644–2658, 2011. View at Publisher · View at Google Scholar · View at Scopus
- J. Tao, W. Liu, G. Shang et al., “MiR-207/352 regulate lysosomal-associated membrane proteins and enzymes following ischemic stroke,” Neuroscience, vol. 305, pp. 1–14, 2015. View at Publisher · View at Google Scholar · View at Scopus
- A. Gombozhapova, Y. Rogovskaya, V. Shurupov et al., “Macrophage activation and polarization in post-infarction cardiac remodeling,” Journal of Biomedical Science, vol. 24, no. 1, p. 13, 2017. View at Publisher · View at Google Scholar · View at Scopus
- M. Pennati, A. Lopergolo, and V. Profumo, “miR-205 impairs the autophagic flux and enhances cisplatin cytotoxicity in castration-resistant prostate cancer cells,” Biochemical Pharmacology, vol. 87, no. 4, pp. 579–597, 2014. View at Publisher · View at Google Scholar
- F. Xu, Y. H. Kang, H. Zhang et al., “Akt1 comprised antibacterial response through regulating macrophage polarization,” The Journal of Infectious Diseases, vol. 208, no. 3, pp. 528–538, 2013. View at Publisher · View at Google Scholar
- Y. Zhang, M. Zhang, X. Li et al., “Silencing MicroRNA-155 attenuates cardiac injury and dysfunction in viral myocarditis via promotion of M2 phenotype polarization of macrophages,” Scientific Reports, vol. 6, article 22613, 2016. View at Publisher · View at Google Scholar
- A. C. Rothchild, J. R. Sissons, S. Shafiani et al., “MiR-155-regulated molecular network orchestrates cell fate in the innate and adaptive immune response to Mycobacterium tuberculosis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 41, pp. E6172–E6181, 2016. View at Publisher · View at Google Scholar · View at Scopus
- C. Wang, C. Zhang, L. Liu et al., “Macrophage-derived mir-155-containing exosomes suppress fibroblast proliferation and promote fibroblast inflammation during cardiac injury,” Molecular Therapy, vol. 25, no. 1, pp. 192–204, 2017. View at Publisher · View at Google Scholar · View at Scopus
- J. L. Bao and L. Lin, “Mir-155 and mir-148a reduce cardiac injury by inhibiting nf-kappab pathway during acute viral myocarditis,” European Review for Medical and Pharmacological Sciences, vol. 18, pp. 2349–2356, 2014. View at Google Scholar
- X.-Q. Wu, Y. Dai, Y. Yang et al., “Emerging role of microRNAs in regulating macrophage activation and polarization in immune response and inflammation,” Immunology, vol. 148, no. 3, pp. 237–248, 2016. View at Publisher · View at Google Scholar · View at Scopus
- S.-W. Kim, K. Ramasamy, H. Bouamar, A.-P. Lin, D. Jiang, and R. C. T. Aguiar, “MicroRNAs miR-125a and miR-125b constitutively activate the NF-kappaB pathway by targeting the tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20),” Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 20, pp. 7865–7870, 2012. View at Publisher · View at Google Scholar · View at Scopus
- S. Banerjee, H. Cui, N. Xie et al., “miR-125a-5p regulates differential activation of macrophages and inflammation,” The Journal of Biological Chemistry, vol. 288, no. 49, pp. 35428–35436, 2013. View at Publisher · View at Google Scholar
- C. I. Caescu, X. Guo, L. Tesfa et al., “Colony stimulating factor-1 receptor signaling networks inhibit mouse macrophage inflammatory responses by induction of microRNA-21,” Blood, vol. 125, no. 8, pp. e1–e13, 2015. View at Publisher · View at Google Scholar
- W. Ying, A. Tseng, R. C.-A. Chang et al., “MicroRNA-223 is a crucial mediator of PPARγ-regulated alternative macrophage activation,” Journal of Clinical Investigation, vol. 125, no. 11, pp. 4149–4159, 2015. View at Publisher · View at Google Scholar · View at Scopus
- F. Yao, Y. Yu, L. Feng et al., “Adipogenic miR-27a in adipose tissue upregulates macrophage activation via inhibiting PPARγ of insulin resistance induced by high-fat diet-associated obesity,” Experimental Cell Research, vol. 355, pp. 105–112, 2017. View at Publisher · View at Google Scholar · View at Scopus
- V. N. Garikipati, S. K. Verma, D. Jolardarashi et al., “Therapeutic inhibition of miR-375 attenuates post-myocardial infarction inflammatory response and left ventricular dysfunction via PDK-1-AKT signalling axis,” Cardiovascular Research, vol. 113, no. 8, pp. 938–949, 2017. View at Publisher · View at Google Scholar
- S. Suresh Babu, R. A. Thandavarayan, D. Joladarashi et al., “MicroRNA-126 overexpression rescues diabetes-induced impairment in efferocytosis of apoptotic cardiomyocytes,” Scientific Reports, vol. 6, Article ID 36207, 2016. View at Publisher · View at Google Scholar · View at Scopus
- M. Yuan, L. Zhang, F. You et al., “MiR-145-5p regulates hypoxia-induced inflammatory response and apoptosis in cardiomyocytes by targeting CD40,” Molecular and Cellular Biochemistry, vol. 431, pp. 123–131, 2017. View at Publisher · View at Google Scholar · View at Scopus
- M. Gao, X. Wang, X. Zhang et al., “Attenuation of cardiac dysfunction in polymicrobial sepsis by MicroRNA-146a is mediated via targeting of IRAK1 and TRAF6 expression,” Journal of Immunology, vol. 195, no. 2, pp. 672–682, 2015. View at Publisher · View at Google Scholar · View at Scopus
- D. A. Chistiakov, A. N. Orekhov, and Y. V. Bobryshev, “The role of miR-126 in embryonic angiogenesis, adult vascular homeostasis, and vascular repair and its alterations in atherosclerotic disease,” Journal of Molecular and Cellular Cardiology, vol. 97, pp. 47–55, 2016. View at Publisher · View at Google Scholar · View at Scopus
- C.-Y. Chen, C.-M. Su, C.-J. Hsu et al., “CCN1 promotes vegf production in osteoblasts and induces endothelial progenitor cell angiogenesis by inhibiting mir-126 expression in rheumatoid arthritis,” Journal of Bone and Mineral Research, vol. 32, no. 1, pp. 34–45, 2017. View at Publisher · View at Google Scholar · View at Scopus
- Y. Chen and D. H. Gorski, “Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5,” Blood, vol. 111, no. 3, pp. 1217–1226, 2008. View at Publisher · View at Google Scholar · View at Scopus
- C. Lu, X. Wang, T. Ha et al., “Attenuation of cardiac dysfunction and remodeling of myocardial infarction by microRNA-130a are mediated by suppression of PTEN and activation of PI3K dependent signaling,” Journal of Molecular and Cellular Cardiology, vol. 89, pp. 87–97, 2015. View at Publisher · View at Google Scholar · View at Scopus
- J. T. Mendell, “miRiad roles for the miR-17-92 cluster in development and disease,” Cell, vol. 133, no. 2, pp. 217–222, 2008. View at Publisher · View at Google Scholar · View at Scopus
- P. Fasanaro, Y. D'Alessandra, V. Di Stefano et al., “MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand ephrin-A3,” Journal of Biological Chemistry, vol. 283, no. 23, pp. 15878–15883, 2008. View at Publisher · View at Google Scholar · View at Scopus
- K. Pulkkinen, T. Malm, M. Turunen, J. Koistinaho, and S. Ylä-Herttuala, “Hypoxia induces microRNA miR-210 in vitro and in vivo,” FEBS Letters, vol. 582, no. 16, pp. 2397–2401, 2008. View at Publisher · View at Google Scholar · View at Scopus
- T. Würdinger, B. A. Tannous, O. Saydam et al., “miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells,” Cancer Cell, vol. 14, no. 5, pp. 382–393, 2008. View at Publisher · View at Google Scholar · View at Scopus
- D. Y. Lee, Z. Deng, C. H. Wang, and B. B. Yang, “MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1 expression,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 51, pp. 20350–20355, 2007. View at Publisher · View at Google Scholar · View at Scopus
- C. Templin, J. Volkmann, M. Y. Emmert et al., “Increased proangiogenic activity of mobilized CD34 + progenitor cells of patients with acute ST-segment-elevation myocardial infarction: Role of differential MicroRNA-378 expression,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 37, no. 2, pp. 341–349, 2017. View at Publisher · View at Google Scholar · View at Scopus
- S. Anand, B. K. Majeti, L. M. Acevedo et al., “MicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis,” Nature Medicine, vol. 16, no. 8, pp. 909–914, 2010. View at Publisher · View at Google Scholar · View at Scopus
- Q. Zhou, R. Gallagher, R. Ufret-Vincenty, X. Li, E. N. Olson, and S. Wang, “Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23~27~24 clusters,” Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 20, pp. 8287–8292, 2011. View at Publisher · View at Google Scholar · View at Scopus
- D. Veliceasa, D. Biyashev, G. Qin et al., “Therapeutic manipulation of angiogenesis with miR-27b,” Vascular Cell, vol. 7, no. 1, article 6, 2015. View at Publisher · View at Google Scholar · View at Scopus
- J. Fiedler, V. Jazbutyte, B. C. Kirchmaier et al., “MicroRNA-24 regulates vascularity after myocardial infarction,” Circulation, vol. 124, no. 6, pp. 720–730, 2011. View at Publisher · View at Google Scholar · View at Scopus
- M. Meloni, M. Marchetti, K. Garner et al., “Local inhibition of microRNA-24 improves reparative angiogenesis and left ventricle remodeling and function in mice with myocardial infarction,” Molecular Therapy, vol. 21, no. 7, pp. 1390–1402, 2013. View at Publisher · View at Google Scholar · View at Scopus
- Q. Duan, L. Yang, W. Gong et al., “MicroRNA-214 is upregulated in heart failure patients and suppresses XBP1-mediated endothelial cells angiogenesis,” Journal of Cellular Physiology, vol. 230, no. 8, pp. 1964–1973, 2015. View at Publisher · View at Google Scholar · View at Scopus
- B. C. Bernardo, X.-M. Gao, C. E. Winbanks et al., “Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function,” Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 43, pp. 17615–17620, 2012. View at Publisher · View at Google Scholar · View at Scopus
- T. Ito, S. Yagi, and M. Yamakuchi, “MicroRNA-34a regulation of endothelial senescence,” Biochemical and Biophysical Research Communications, vol. 398, no. 4, pp. 735–740, 2010. View at Publisher · View at Google Scholar · View at Scopus
- T. Zhao, J. Li, and A. F. Chen, “MicroRNA-34a induces endothelial progenitor cell senescence and impedes its angiogenesis via suppressing silent information regulator 1,” American Journal of Physiology—Endocrinology and Metabolism, vol. 299, no. 1, pp. E110–E116, 2010. View at Publisher · View at Google Scholar · View at Scopus
- L. Xiao, H. He, L. Ma et al., “Effects of mir-29a and mir-101a expression on myocardial interstitial collagen generation after aerobic exercise in myocardial-infarcted rats,” Archives of Medical Research, vol. 48, no. 1, pp. 27–34, 2017. View at Publisher · View at Google Scholar
- L. P. Zhu, J. P. Zhou, J. X. Zhang et al., “Mir-15b-5p regulates collateral artery formation by targeting akt3 (protein kinase b-3),” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 37, no. 5, pp. 957–968, 2017. View at Publisher · View at Google Scholar
- S. Grundmann, F. P. Hans, S. Kinniry et al., “MicroRNA-100 regulates neovascularization by suppression of mammalian target of rapamycin in endothelial and vascular smooth muscle cells,” Circulation, vol. 123, no. 9, pp. 999–1009, 2011. View at Publisher · View at Google Scholar · View at Scopus
- C. P. Bracken, P. A. Gregory, and N. Kolesnikoff, “A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition,” Cancer Research, vol. 68, no. 19, pp. 7846–7854, 2008. View at Publisher · View at Google Scholar · View at Scopus
- P. A. Gregory, A. G. Bert, E. L. Paterson et al., “The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1,” Nature Cell Biology, vol. 10, no. 5, pp. 593–601, 2008. View at Publisher · View at Google Scholar · View at Scopus
- Y. C. Chan, S. Roy, S. Khanna, and C. K. Sen, “Downregulation of endothelial microRNA-200b supports cutaneous wound angiogenesis by desilencing GATA binding protein 2 and vascular endothelial growth factor receptor 2,” Arteriosclerosis, Thrombosis, & Vascular Biology, vol. 32, no. 6, pp. 1372–1382, 2012. View at Publisher · View at Google Scholar · View at Scopus
- Y.-C. Choi, S. Yoon, Y. Jeong, J. Yoon, and K. Baek, “Regulation of vascular endothelial growth factor signaling by miR-200b,” Molecules and Cells, vol. 32, no. 1, pp. 77–82, 2011. View at Publisher · View at Google Scholar · View at Scopus
- A. Caporali, M. Meloni, C. Völlenkle et al., “Deregulation of microRNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia,” Circulation, vol. 123, no. 3, pp. 282–291, 2011. View at Publisher · View at Google Scholar · View at Scopus
- K.-J. Yin, K. Olsen, M. Hamblin, J. Zhang, S. P. Schwendeman, and Y. E. Chen, “Vascular endothelial cell-specific MicroRNA-15a inhibits angiogenesis in hindlimb ischemia,” Journal of Biological Chemistry, vol. 287, no. 32, pp. 27055–27064, 2012. View at Publisher · View at Google Scholar · View at Scopus
- A. Chamorro-Jorganes, E. Araldi, L. O. F. Penalva, D. Sandhu, C. Fernández-Hernando, and Y. Suárez, “MicroRNA-16 and MicroRNA-424 regulate cell-autonomous angiogenic functions in endothelial cells via targeting vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 31, no. 11, pp. 2595–2606, 2011. View at Publisher · View at Google Scholar · View at Scopus
- X. H. Wang, R. Z. Qian, W. Zhang, S. F. Chen, H. M. Jin, and R. M. Hu, “MicroRNA-320 expression in myocardial microvascular endothelial cells and its relationship with insulin-like growth factor-1 in type 2 diabetic rats,” Clinical and Experimental Pharmacology & Physiology, vol. 36, no. 2, pp. 181–188, 2009. View at Publisher · View at Google Scholar · View at Scopus
- X. Wang, W. Huang, G. Liu et al., “Cardiomyocytes mediate anti-angiogenesis in type 2 diabetic rats through the exosomal transfer of miR-320 into endothelial cells,” Journal of Molecular and Cellular Cardiology, vol. 74, pp. 139–150, 2014. View at Publisher · View at Google Scholar
- P. Wang, Y. Luo, H. Duan et al., “MicroRNA 329 Suppresses Angiogenesis by Targeting CD146,” Molecular and Cellular Biology, vol. 33, no. 18, pp. 3689–3699, 2013. View at Publisher · View at Google Scholar · View at Scopus
- C. Ohyagi-Hara, K. Sawada, S. Kamiura et al., “MiR-92a inhibits peritoneal dissemination of ovarian cancer cells by inhibiting integrin α5 expression,” The American Journal of Pathology, vol. 182, no. 5, pp. 1876–1889, 2013. View at Publisher · View at Google Scholar · View at Scopus
- A. Bonauer, G. Carmona, M. Iwasaki et al., “MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in Mice,” Science, vol. 324, no. 5935, pp. 1710–1713, 2009. View at Publisher · View at Google Scholar · View at Scopus
- R. Hinkel, D. Penzkofer, S. Zühlke et al., “Inhibition of microRNA-92a protects against ischemia/reperfusion injury in a large-animal model,” Circulation, vol. 128, no. 10, pp. 1066–1075, 2013. View at Publisher · View at Google Scholar · View at Scopus
- Z. Jing, W. Han, X. Sui, J. Xie, and H. Pan, “Interaction of autophagy with microRNAs and their potential therapeutic implications in human cancers,” Cancer Letters, vol. 356, no. 2, pp. 332–338, 2015. View at Publisher · View at Google Scholar · View at Scopus
- L. Bao, L. Lv, J. Feng et al., “Mir-487b-5p regulates temozolomide resistance of lung cancer cells through lamp2-medicated autophagy,” DNA and Cell Biology, vol. 35, no. 8, pp. 385–392, 2016. View at Publisher · View at Google Scholar · View at Scopus
- Y. Lim and S. Kumar, “A single cut to pyroptosis,” Oncotarget, vol. 6, no. 35, pp. 36926-36927, 2015. View at Publisher · View at Google Scholar · View at Scopus
- P. Jeyabal, R. A. Thandavarayan, D. Joladarashi et al., “MicroRNA-9 inhibits hyperglycemia-induced pyroptosis in human ventricular cardiomyocytes by targeting ELAVL1,” Biochemical and Biophysical Research Communications, vol. 471, no. 4, pp. 423–429, 2016. View at Publisher · View at Google Scholar · View at Scopus
- F. Bauernfeind, A. Rieger, F. A. Schildberg, P. A. Knolle, J. L. Schmid-Burgk, and V. Hornung, “NLRP3 inflammasome activity is negatively controlled by miR-223,” Journal of Immunology, vol. 189, no. 8, pp. 4175–4181, 2012. View at Publisher · View at Google Scholar · View at Scopus
- P. Carmeliet, “Angiogenesis in life, disease and medicine,” Nature, vol. 438, no. 7070, pp. 932–936, 2005. View at Publisher · View at Google Scholar · View at Scopus
- J. S. Esser, E. Saretzki, F. Pankratz et al., “Bone morphogenetic protein 4 regulates microRNAs miR-494 and miR-126–5p in control of endothelial cell function in angiogenesis,” Thrombosis and Haemostasis, vol. 117, no. 4, pp. 734–749, 2017. View at Publisher · View at Google Scholar
- C. Doebele, A. Bonauer, A. Fischer et al., “Members of the microRNA-17–92 cluster exhibit a cell-intrinsic antiangiogenic function in endothelial cells,” Blood, vol. 115, no. 23, pp. 4944–4950, 2010. View at Publisher · View at Google Scholar · View at Scopus
- M. Dews, A. Homayouni, D. Yu et al., “Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster,” Nature Genetics, vol. 38, no. 9, pp. 1060–1065, 2006. View at Publisher · View at Google Scholar · View at Scopus