|
| miRNAs | Targets | Effector cells (Tissue) | References |
|
| miRNAs regulate the induction of autophagy |
| miR-106b | ULKl | C2C12 (myoblast cells) | [108] |
| miR-25 | ULKl | MCF-7 (breast cancer) | [109] |
| miR-17-5p | ULKl | TIB-71 (murine macrophage cells) | [110] |
| miR-4487 | ULKl | SH-SY5Y (neuroblastoma) | [17] |
| miR-595 | ULKl | SH-SY5Y (neuroblastoma) | [17] |
| miR-885-3p | ULK2 | JHU-029 (squamous cell carcinoma) | [111] |
| miR-26b | ULK2 | PC3, C4-2 (prostate cancer) | [112] |
|
| miRNAs regulate the vesicle nucleation of autophagy |
| miR-30a | Beclin-1 | 786-0, A489 (renal carcinoma), MG-63 (osteosarcoma) | [113, 114] |
| miR-384-5p | Beclin-1 | primary mouse macrophages | [115] |
| miR-409-3p | Beclin-1 | Lovo Oxa R (colorectal cancer) | [116] |
| miR -216a | Beclin-1 | PANC-1 (pancreas cancer) | [117] |
| miR-630 | UVRAG | JHU-029 (squamous cell carcinoma) | [118] |
| miR-374a | UVRAG | JHU-029 (squamous cell carcinoma) | [118] |
|
| miRNAs regulate the vesicle elongation and retrieval of autophagy |
| miR-181a | Atg5 | MCF-7 (breast cancer) Huh7 (liver cancer) K562 (chronic myelogenous leukemia) | [119] |
| miR-224-3p | Atg5 | U251 and U87 (glioblastoma) | [120] |
| miR-30a | Atg5 | K562 (CML) | [121] |
| miR-30d | Atg16 | A2780, OVCAR10 and 2008 (ovarian cancer), T47D and MCF-7 (breast cancer) | [122] |
| miR-375 | ATG7 | Huh7, Hep3B (liver cancer) | [123] |
| miR-20a | ATG7 | SiHa (cervical cancer) | [124] |
| miR-137 | ATG7 | U87 (glioblastoma) | [125] |
| miR-96 | ATG7 | LNCaP, 22Rv1, and LAPC4 (prostate cancer) | [32] |
| miR-188-3p | ATG7 | NMCMs | [126] |
| miR-199a-5p | ATG7 | Huh7, HepG2 (liver cancer) | [127] |
| miR-519A | ATG16, ATG10 | JHU-029 (squamous cell carcinoma) | [118] |
| miR-376a/b | ATG4C | MCF-7 (breast cancer) Huh7 (liver cancer) | [128, 129] |
| miR-101 | ATG4D | MCF-7 (breast cancer) | [130] |
| miR-382 | LC3 | renal mesangial cells | [131] |
| miR-21 | LC3-II | diabetic mesangial cell | [132] |
| MiR-130a | Atg2B | MEC-1 (leukemia) | [133] |
| miR-143 | Atg2B | H1299 (lung cancer) | [134] |
| miR-34a | Atg9 | NMCMs | [135] |
|
| miRNAs regulate the formation and degradation of autolysosome |
| miR-502 | RAB1B | HCT116 (colorectal cancer) | [136] |
| miR-451 | RAB14 | A549, SPC-A1, and NCI-H520 (lung cancer) | [137] |
| miR-207 | LAMP2 | primary cortical neuronal cells | [138] |
| miR-487-5p | LAMP2 | A549, H1299 (lung cancer) | [139] |
| miR-205 | RAB27A, LAMP3 | DU145, PC3 (prostate cancer) | [140] |
|
